Does vagal nerve stimulation alter immune response in the brain?
Project/Area Number |
25861275
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Neurosurgery
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Research Institution | Osaka University |
Principal Investigator |
KHOO Hui Ming 大阪大学, 医学部附属病院, 特任研究員 (70591022)
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Project Period (FY) |
2013-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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Keywords | てんかん / 免疫 / HMGB1 / 迷走神経刺激 / サイトカイン / HMGb1 |
Outline of Final Research Achievements |
Increasing evidence supports the involvement of activation of Toll-like receptor 4 (TLR4), a key receptor of innate immunity, by the high-mobility group box-1 (HMGB1) in the etiopathogenesis of seizures. Vagal nerve stimulation (VNS) was proposed to alter norepinephrine (NE) release by projections to the locus coeruleus. NE is known to be an inhibitor of inflammatory responses in the brain. Using model of acute seizures in Wistar rat, we discovered a mechanism of VNS in seizure control involving suppression of HMGB1 release from neurons.
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Report
(3 results)
Research Products
(68 results)
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[Journal Article] Default mode network connectivity in patients with idiopathic normal pressure hydrocephalus2015
Author(s)
Khoo Hui Ming, Kishima Haruhiko, Tani Naoki, Oshino Satoru, Maruo Tomoyuki, Hosomi Koichi, Yanagisawa Takufumi, Kazui Hiroaki, Watanabe Yoshiyuki, Shimokawa Toshio, Aso Toshihiko, Atsushi Kawaguchi, Yamashita Fumio, SaitohYouichi, Yoshimine Toshiki
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Journal Title
Journal of Neurosurgery
Volume: 未定
Related Report
Peer Reviewed
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[Journal Article] Low-frequency subthalamic nucleus stimulation in Parkinson's disease: a randomized clinical trial.2014
Author(s)
Khoo HM, Kishima H, Hosomi K, Maruo T, Tani N, Oshino S, Shimokawa T, Yokoe M, Mochizuki H, Saitoh Y, Yoshimine T.
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Journal Title
Mov Disord.
Volume: 29(2)
Issue: 2
Pages: 2270-4
DOI
Related Report
Peer Reviewed
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[Journal Article] Which is the Most Appropriate Disconnection Surgery for Refractory Epilepsy in Childhood?2013
Author(s)
Kishima H, Oshoni S, Tani N, Maruo T, Morris S, Khoo HM, Yanagisawa T, Shimono K, Okinaga T, Hirata M, Kato A, Yoshimine T.
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Journal Title
Neurologia medico-chirurgica
Volume: 53
Issue: 11
Pages: 814-820
DOI
NAID
ISSN
0470-8105, 1349-8029
Related Report
Peer Reviewed
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[Presentation] Alternation of cross frequency coupling in the pre-ictal iEEG of epileptic patients2014
Author(s)
Edagawa K, Kishima H, Yanagisawa T, Oshino S, Inoue Y, Kobayashi M, Hosomi K, Khoo HM, Hirata M, Yoshimine T
Organizer
2014 Annual Meeting of the American Epilepsy Society
Place of Presentation
Seattle, USA
Year and Date
2014-12-05 – 2014-12-09
Related Report
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[Presentation] Frameless image-guided stereotactic implantation of depth electrodes via craniotomy for pharmacoresistant epilepsy2014
Author(s)
Khoo HM, Kishima H, Oshino S, Tani N, Maruo T, Yanagisawa T, Edagawa K, Inoue Y, Hirata M, Yoshimine T
Organizer
2014 Annual Meeting of the American Epilepsy Society
Place of Presentation
Seattle, USA
Year and Date
2014-12-05 – 2014-12-09
Related Report
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[Presentation] Surgery for refractory epilepsy with MRI positive lesions in childhood2014
Author(s)
Kishima H, Oshino S, Khoo HM, Kobayashi M, Yanagisawa T, Edagawa K, Hosomi K, Inoue Y, Shimizu T, Hirata M, Yoshimine T
Organizer
The 8th Asian Epilepsy Surgery Congress
Place of Presentation
Tokyo,Japan
Year and Date
2014-10-04 – 2014-10-06
Related Report
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[Presentation] Frameless image-guided stereotactic implantation of depth electrodes via craniotomy for pharmacoresistant epilepsy2014
Author(s)
Khoo HM, Kishima H, Oshino S, Tani N, Maruo T, Yanagisawa T, Edagawa K, Inoue Y, Hirata M, Yoshimine T
Organizer
The 8th Asian Epilepsy Surgery Congress
Place of Presentation
Tokyo,Japan
Year and Date
2014-10-04 – 2014-10-06
Related Report
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[Presentation] Alternation of cross frequency coupling in the pre-ictal iEEG of epileptic patients2014
Author(s)
Edagawa K, Kishima H, Yanagisawa T, Oshino S, Inoue Y, Kobayashi M, Hosomi K, Khoo HM, Hirata M, Yoshimine T
Organizer
The 8th Asian Epilepsy Surgery Congress
Place of Presentation
Tokyo,Japan
Year and Date
2014-10-04 – 2014-10-06
Related Report
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[Presentation] The efficacy of the study with intracranial electroencephalography in relation to epileptic pathology2014
Author(s)
Oshino S, Kishima H, Hirata M, Yanagisawa T, Edagawa K, Khoo HM, Inoue Y, Tani N, Kobayashi M, Yoshimine T
Organizer
The 8th Asian Epilepsy Surgery Congress
Place of Presentation
Tokyo,Japan
Year and Date
2014-10-04 – 2014-10-06
Related Report
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