| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
|
|---|
| Outline of Final Research Achievements |
Increasing evidence supports the involvement of activation of Toll-like receptor 4 (TLR4), a key receptor of innate immunity, by the high-mobility group box-1 (HMGB1) in the etiopathogenesis of seizures. Vagal nerve stimulation (VNS) was proposed to alter norepinephrine (NE) release by projections to the locus coeruleus. NE is known to be an inhibitor of inflammatory responses in the brain. Using model of acute seizures in Wistar rat, we discovered a mechanism of VNS in seizure control involving suppression of HMGB1 release from neurons.
|
