The role of rac in recovery of motor function after central nervous system injury

Research Project

Project/Area Number	25861276
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Neurosurgery
Research Institution	Kobe University
Principal Investigator	KOHTA MASAAKI 神戸大学, 医学(系)研究科(研究院), 助教 (80590843)
Project Period (FY)	2013-04-01 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000) Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000) Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	アストロサイト / Rac1 / 中枢神経損傷 / 脊髄損傷 / 神経機能回復
Outline of Final Research Achievements	The present study demonstrated that in astrocyte-specific Rac1 knockout mice the recovery of the motor function after spinal cord injury was enhanced and reactive astrocyte around injury decreased. Knockdown of Rac1 expression in LN229 cells decreased cell migration and proliferation.

Report

(3 results)