Analysis of differentiation mechanism of oligodendrocyte for clinical application of demyelinating disease therapy

Research Project

Project/Area Number	25861281
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Neurosurgery
Research Institution	Kochi University
Principal Investigator	MASAHIRA Noritaka 高知大学, 教育研究部医療学系, 講師 (80444769)
Project Period (FY)	2013-04-01 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000) Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2013: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords	脱髄疾患 / オリゴデンドロサイト / Olig2 / 神経分化 / 再生医療
Outline of Final Research Achievements	To elucidate function of bHLH transcriptional factor Olig2, gene expression pattern of fetal spinal cords between wild type mice and Olig2 knock-out mice was investigated with DNA subtraction method. Twelve genes were identified as candidates of downstream factors of Olig2 and expression patterns of theses genes were examined. Peroxiredoxin 1 was expressed specifically in the location of motoneurons, and was presumed to concern with differentiation for motoneurons.

Report

(3 results)