Analysis of differentiation mechanism of oligodendrocyte for clinical application of demyelinating disease therapy
Project/Area Number |
25861281
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Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Neurosurgery
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Research Institution | Kochi University |
Principal Investigator |
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Project Period (FY) |
2013-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
|
Keywords | 脱髄疾患 / オリゴデンドロサイト / Olig2 / 神経分化 / 再生医療 |
Outline of Final Research Achievements |
To elucidate function of bHLH transcriptional factor Olig2, gene expression pattern of fetal spinal cords between wild type mice and Olig2 knock-out mice was investigated with DNA subtraction method. Twelve genes were identified as candidates of downstream factors of Olig2 and expression patterns of theses genes were examined. Peroxiredoxin 1 was expressed specifically in the location of motoneurons, and was presumed to concern with differentiation for motoneurons.
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Report
(3 results)
Research Products
(2 results)