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Development of hypoxia-imaging in brain tumors using 7 Tesla MRI

Research Project

Project/Area Number 25861287
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Neurosurgery
Research InstitutionIwate Medical University

Principal Investigator

UWANO Ikuko  岩手医科大学, 医学部, 助教 (20468317)

Research Collaborator KUDO Kohsuke  
OGASAWARA Kuniaki  
BEPPU Takaaki  
SASAKI Makoto  
Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords7テスラMRI / 定量的磁化率マップ / 酸素摂取率 / 位相画像 / 脳腫瘍 / 低酸素イメージング
Outline of Final Research Achievements

In this study, we evaluated the performance and efficacy for intensity inhomogeneity correction of various sequences of the human brain in 7 Tesla MRI using the extended version of the unified segmentation algorithm, and we found all of these intensity inhomogeneities were successfully corrected and the contrast between different tissue types was maintained after inhomogeneity correction. In addition, we investigated whether oxygen extraction fraction (OEF) maps that were generated with a quantitative susceptibility mapping (QSM) technique at 7 Tesla would demonstrate OEF changes in patients with major cerebrovascular steno-occlusive disease compared with OEF maps that were generated with PET, and as a result the OEF ratios on QSM-OEF maps at 7 Tesla correlated well with those on PET-OEF maps in patients with steno-occlusive cerebrovascular diseases.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (9 results)

All 2015 2014 2013

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (5 results)

  • [Journal Article] Assessment of Sensations Experienced by Subjects during MR Imaging Examination at 7T2015

    • Author(s)
      Uwano I, Metoki T, Sendai F, Yoshida R, Kudo K, Yamashita F, Higuchi S, Ito K, Harada T, Goodwin J, Ogawa A, Sasaki M
    • Journal Title

      Magnetic Resonance in Medical Sciences

      Volume: 14 Issue: 1 Pages: 35-41

    • DOI

      10.2463/mrms.2014-0004

    • NAID

      130004700395

    • ISSN
      1347-3182, 1880-2206
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Susceptibility-Weighted Phase Imaging and Oxygen Extraction Fraction Measurement during Sedation and Sedation Recovery using 7T MRI2014

    • Author(s)
      Jonathan A. Goodwin, Kohsuke Kudo, Yutaka Shinohe, Satomi Higuchi, Ikuko Uwano, Fumio Yamashita and Makoto Sasaki
    • Journal Title

      Journal of Neuroimaging

      Volume: 00 Issue: 4 Pages: 1-7

    • DOI

      10.1111/jon.12192

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Bayesian Analysis of Perfusion-weighted Imaging to Predict Infarct Volume: Comparison with Singular Value Decomposition2014

    • Author(s)
      Kudo K, Boutelier T, Pautot F, Honjo K, Hu JQ, Wang HB, Shintaku K, Uwano I, Sasaki M
    • Journal Title

      Magnetic Resonance in Medical Sciences

      Volume: 13 Issue: 1 Pages: 45-50

    • DOI

      10.2463/mrms.2013-0085

    • NAID

      130003392992

    • ISSN
      1347-3182, 1880-2206
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intensity inhomogeneity correction for magnetic resonance imaging of human brain at 7T2014

    • Author(s)
      Uwano I, Kudo K, Yamashita F, Goodwin J, Higuchi S, Ito K, Harada T, Ogawa A, Sasaki M
    • Journal Title

      Med Phys

      Volume: 41(2) Issue: 2 Pages: 22302-22302

    • DOI

      10.1118/1.4860954

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Measurement of Oxygen Extraction Fraction in Patients with Steno-occlusive Cerebrovascular Diseases using Quantitative Susceptibility Mapping at 7T2015

    • Author(s)
      Uwano I, Sasaki M, Kudo K, Sato R, Sato Y, Ogasawara Y, Saura H, Ogasawara K, Harada T, Ito K, Yamashita F, Goodwin J, Higuchi S
    • Organizer
      ISMRM 23rd Annual Meeting
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      2015-05-30 – 2015-06-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] 7T-MRIの定量的磁化率マップによるOEF計測:主幹動脈病変患者のPET画像との比較2015

    • Author(s)
      上野 育子、佐々木 真理、工藤 與亮、佐藤 良太、小笠原 邦昭、原田 太以佑、伊藤 賢司、山下 典生、樋口 さとみ
    • Organizer
      第38回日本脳神経CI学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-02-13 – 2015-02-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] 7 Tesla定量的磁化率マップ(QSM)を用いたOEF画像:主幹動脈病変患者への応用とPETとの比較2014

    • Author(s)
      上野 育子、工藤 與亮、佐藤 良太、佐藤 由衣子、小笠原 靖、佐浦 宏明、小笠原 邦昭、ジョナサン グッドウィン、山下 典生、樋口さとみ、伊藤 賢司、原田 太以佑、佐々木 真理
    • Organizer
      第21回東北脳循環カンファランス
    • Place of Presentation
      仙台
    • Year and Date
      2014-10-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] Subjective Assessment of Sensations Experienced by 7 Tesla Magnetic Resonance Imaging2014

    • Author(s)
      Uwano I, Metoki T, Sendai F, Yoshida R, Kudo K, Yamashita F, Higuchi S, Ito K, Harada T, Goodwin J, Sasaki M
    • Organizer
      Joint Annual Meeting ISMRM-ESMRMB 2014
    • Place of Presentation
      Milan, Italy
    • Year and Date
      2014-05-10 – 2014-05-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] Intensity Inhomogeneity Correction in Human Brain Imaging at 7 Tesla using SPM82013

    • Author(s)
      Uwano I, Kudo K, Yamashita F, Metoki T, Goodwin J, Higuchi S, Ito K, Yokosawa S, Sasaki M
    • Organizer
      ISMRM 21st Annual Meeting
    • Place of Presentation
      Salt Lake City, USA
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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