Influence of astrocyte in traumatic brain injury
| Project/Area Number |
25861292
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurosurgery
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| Research Institution | Nihon University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | アストロサイト / 脳挫傷 / グリオトランスミッター / マイクログリア / グリア / サイトカイン |
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| Outline of Final Research Achievements |
In this study, we investigated if suppression of gliotransmitter potent therapeutic effect in a rat traumatic injury model. Rat cerebral contusion model was made and either cerebrospinal fluid or MRS2179, a selective P2Y1 blocker was in situ administrated. Galectin-3 was used as a marker of active microglia. Galectin-3 positive amoeboid microglia was observed mainly around the contused tissue from 1 day after injury. Administration of MRS2179 significantly suppressed the expression of Galectin-3 after day 3. MRS2179 injection improved some behavioral test score.
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Report
(3 results)
Research Products
(1 results)
