Influence of astrocyte in traumatic brain injury

Research Project

Project/Area Number	25861292
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Neurosurgery
Research Institution	Nihon University
Principal Investigator	MORO Nobuhiro 日本大学, 医学部, 助手 (00386012)
Project Period (FY)	2013-04-01 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000) Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords	アストロサイト / 脳挫傷 / グリオトランスミッター / マイクログリア / グリア / サイトカイン
Outline of Final Research Achievements	In this study, we investigated if suppression of gliotransmitter potent therapeutic effect in a rat traumatic injury model. Rat cerebral contusion model was made and either cerebrospinal fluid or MRS2179, a selective P2Y1 blocker was in situ administrated. Galectin-3 was used as a marker of active microglia. Galectin-3 positive amoeboid microglia was observed mainly around the contused tissue from 1 day after injury. Administration of MRS2179 significantly suppressed the expression of Galectin-3 after day 3. MRS2179 injection improved some behavioral test score.

Report

(3 results)