| Project/Area Number |
25861294
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurosurgery
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| Research Institution | Osaka Medical College |
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Principal Investigator |
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| Research Collaborator |
KAWABATA Shinji 大阪医科大学, 医学部, 講師 (20340549)
FURUSE Motomasa 大阪医科大学, 医学部, 講師 (70340560)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | PET / glioma / 血液灌流 / 病態診断 / 悪性神経膠腫 / 画像診断 / 病態解析 |
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| Outline of Final Research Achievements |
I showed that 18F-BPA positron emission tomography (PET), using the essential amino acids “phenylalanine” as a PET tracer, was useful in the differentiation of the change after treatment such as recurrence of tumor or the radiation injury / necrosis during the course after malignant glioma treatment.
However, there is not the definition that is yet clear for the interpretation of results obtained by the amino acid PET that we did including 18F-BPA.
In the amino acid PET image, we should think that not only this diagnosis image shows tumor metabolism, but also is affected by tumor tissue blood perfusion. Furthermore, we devised analytical method to lead visualization of "the true amino acid metabolism" and investigated the usefulness about an evaluation and the pathologic diagnosis after treatment of the brain tumor with this technique.
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