The development of new measurement methods in radiographic image.

• Project/Area Number: 25861307
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Orthopaedic surgery
• Research Institution: Nagoya University
• Principal Investigator: Funahashi Koji 名古屋大学, 医学部附属病院, 病院助教 (80566977)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 関節リウマチ / 関節破壊 / 画像解析 / 超解像 / 関節裂隙間距離

Outline of Final Research Achievements

We developed a new measurement methods to detect joint destruction to be found in a finger with rheumatoid arthritis patients in detail.We prepared the radiographic images of finger joints which performed super-resolution image processing.After that we drew curved line on the joint surface of MCP joint with app consisted of MATLAB by several times of manual operation.The measurement results were calculated automatically from the curved line.
These a series of technique applied for a patent.We confirmed improvement of the measurement accuracy of the joint space distance with the X-rays image which performed super-resolution image processing by measuring the distance ten times to adjust the error of measurement compared with conventional image.We validated the measurement value of these methods by radiographic image of a phantom model.

Research Products

• [Journal Article] Predictive factors for achieving low disease activity at 52 weeks after switching from tumor necrosis factor inhibitors to abatacept: results from a multicenter observational cohort study of Japanese patients (2016)
  • Author(s): Kojima, T., Takahashi, N., Kaneko, A., Kida, D., Hirano, Y., Fujibayashi, T., Yabe, Y., Takagi, H., Oguchi, T., Miyake, H., Kato, T., Watanabe, T., Hayashi, M., Shioura, T., Kanayama, Y., Funahashi, K., Asai, S., Yoshioka, Y., Terabe, K., Takemoto, T., Asai, N., Ishiguro, N.
  • Journal Title: Clinical Rheumatology Volume: 35 Issue: 1 Pages: 219-25
  • DOI: 10.1007/s10067-015-3135-3
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] mproved safety of biologic therapy for rheumatoid arthritis over the 8-year period since implementation in Japan: long-term results from a multicenter observational cohort study (2016)
  • Author(s): Kojima, T., Takahashi, N., Funahashi, K., Asai, S., Terabe, K., Kaneko, A., Hirano, Y., Hayashi, M., Miyake, H., Oguchi, T., Takagi, H., Kanayama, Y., Yabe, Y., Watanabe, T., Fujibayashi, T., Shioura, T., Ito, T., Yoshioka, Y., Ishikawa, H., Asai, N., Takemoto, T., Kojima, M., Ishiguro, N.
  • Journal Title: Clinical Rheumatology Volume: 35 Issue: 4 Pages: 863-71
  • DOI: 10.1007/s10067-016-3201-5
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Drug retention rates of second biologic agents after switching from tumor necrosis factor inhibitors for rheumatoid arthritis in Japanese patients on low-dose methotrexate or without methotrexate (2015)
  • Author(s): Kobayakawa, T.,Kojima, T.,Takahashi, N.,Hayashi, M.,Yabe, Y.,Kaneko, A.,Shioura, T.,Saito, K.,Hirano, Y.,Kanayama, Y.,Miyake, H.,Asai, N.,Funahashi, K.,Hirabara, S.,Hanabayashi, M.,Asai, S.,Ishiguro, N.
  • Journal Title: Mod Rheumatol Volume: 25（2） Issue: 2 Pages: 251-256
  • DOI: 10.3109/14397595.2014.953668
  • Peer Reviewed
• [Journal Article] Importance of methotrexate therapy concomitant with tocilizumab treatment in achieving better clinical outcomes for rheumatoid arthritis patients with high disease activity: an observational cohort study (2015)
  • Author(s): Kojima, T.,Yabe, Y.,Kaneko, A.,Takahashi, N.,Funahashi, K.,Kato, D.,Hanabayashi, M.,Asai, S.,Hirabara, S.,,Asai, ,.Hirano, Y.,Hayashi, M.,Miyake, H.,Kojima, M.,Ishiguro, N.
  • Journal Title: Rheumatology (Oxford) Volume: 54（1） Issue: 1 Pages: 113-120
  • DOI: 10.1093/rheumatology/keu302
  • Peer Reviewed
• [Journal Article] Clinical efficacy of abatacept, tocilizumab, and etanercept in Japanese rheumatoid arthritis patients with inadequate response to anti-TNF monoclonal antibodies (2014)
  • Author(s): Y.,Fujibayashi, T.,Sugiura, F.,Hayashi, M.,Funahashi, K.,Hanabayashi, M.,Asai, S.,Ishiguro, N.,Kojima, T.
  • Journal Title: Clin Rheumatol Volume: 33（９） Issue: 9 Pages: 1247-1254
  • DOI: 10.1007/s10067-014-2711-2
  • Peer Reviewed
• [Journal Article] Clinical efficacy of abatacept compared to adalimumab and tocilizumab in rheumatoid arthritis patients with high disease activity (2014)
  • Author(s): Takahashi N, Kojima T, Kaneko A, Kida D, Hirano Y, Fujibayashi T, Yabe Y, Takagi H, Oguchi T, Miyake H, Kato T, Fukaya N, Ishikawa H, Hayashi M, Tsuboi S, Kanayama Y, Kato D, Funahashi K, Matsubara H, Hattori Y, Hanabayashi M, Hirabara S, Terabe K, Yoshioka Y, Ishiguro N.
  • Journal Title: Clin Rheumatol Volume: 33(1) Issue: 1 Pages: 39-47
  • DOI: 10.1007/s10067-013-2392-2
  • Peer Reviewed
• [Journal Article] Monitoring C-reactive protein levels to predict favourable clinical outcomes from tocilizumab treatment in patients with rheumatoid arthritis. (2013)
  • Author(s): Kojima T, Yabe Y, Kaneko A, Hirano Y, Ishikawa H, Hayashi M, Miyake H, Takagi H, Kato T, Terabe K, Wanatabe T, Tsuchiya H, Kida D, Shioura T, Funahashi K, Kato D, Matsubara H, Takahashi N, Hattori Y, Asai N, Ishiguro N.
  • Journal Title: Mod Rheumatol. Volume: 23(5) Issue: 5 Pages: 977-85
  • DOI: 10.1007/s10165-012-0782-y
  • NAID: 10031201157
• [Journal Article] Clinical efficacy of abatacept in Japanese rheumatoid arthritis patients (2013)
  • Author(s): Takahashi N, Kojima T, Kaneko A, Kida D, Hirano Y, Fujibayashi T, Yabe Y, Takagi H, Oguchi T, Miyake H, Kato T, Fukaya N, Ishikawa H, Hayashi M, Tsuboi S, Kanayama Y, Kato D, Funahashi K, Matsubara H, Hattori Y, Hanabayashi M, Hirabara S, Terabe K, Yoshioka Y, Ishiguro N.
  • Journal Title: Mod Rheumatol Volume: 23(5) Issue: 5 Pages: 904-912
  • DOI: 10.1007/s10165-012-0760-4
  • NAID: 10031201146
  • Peer Reviewed
• [Presentation] レントゲン画像における新しい画像計測法 超解像画像処理とカーブフィッティング法を用いた関節裂隙間距離の測定の妥当性 (2016)
  • Author(s): 舟橋 康治,小嶋 俊久, 高橋 伸典, 浅井 秀司, 竹本 東希, 浅井 信之, 渡部 達生, 石黒 直樹
  • Organizer: 第６０回日本リウマチ学会総会・学術集会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-04-21
• [Presentation] 超解像画像処理とカーブフィッティング法を用いた関節裂隙間距離の測定 ～従来の２点間距離の計測との比較～ (2015)
  • Author(s): 舟橋康治 小嶋俊久 高橋伸典 浅井秀司 竹本東希 浅井信之 渡部達生 石黒直樹
  • Organizer: 第27回中部リウマチ学会・日本リウマチ学会中部支部学術集会.
  • Place of Presentation: 愛知県産業労働センターウインクあいち（愛知県名古屋市）
  • Year and Date: 2015-09-04
• [Presentation] レントゲン画像における新しい画像計測方法の開発 超解像画像処理とカーブフィッティング法を用いた関節裂隙間距離の測定 (2015)
  • Author(s): 舟橋 康治, 小嶋 俊久, 高橋 伸典, 浅井 秀司, 吉岡 裕, 竹本 東希, 寺部 健哉, 浅井 信之, 石黒 直樹
  • Organizer: 第59回日本リウマチ学会総会・学術集会
  • Place of Presentation: 名古屋国際会議場（愛知県名古屋市）
  • Year and Date: 2015-04-23
• [Presentation] レントゲン画像における新しい画像計測方法の開発 超解像画像処理とカーブフィッティング法を用いた関節裂隙間距離の測定 (2015)
  • Author(s): 舟橋 康治, 小嶋 俊久, 高橋 伸典, 浅井 秀司, 吉岡 裕, 竹本 東希, 寺部 健哉, 浅井 信之, 石黒 直樹
  • Organizer: 第59回日本リウマチ学会総会・学術集会
  • Place of Presentation: 名古屋国際会議場（愛知県名古屋市）
  • Year and Date: 2015-04-22 – 2015-04-24
• [Presentation] 関節リウマチ患者のレントゲン画像を用いた関節裂隙間距離測定アプリケーションの検討 (2015)
  • Author(s): 清水雅人,後藤富朗,平野智,桜井優,舟橋康治
  • Organizer: コンシューマエレクトロニクス研究会
  • Place of Presentation: 海峡メッセ下関（山口県下関市）
  • Year and Date: 2015-01-23
• [Presentation] 関節リウマチ患者のレントゲン画像における関節裂隙間距離の測定とその有用性 (2014)
  • Author(s): 清水雅人,後藤富朗,平野智,桜井優,舟橋康治
  • Organizer: 映像メディア処理シンポジウム
  • Place of Presentation: ラフォーレ修善寺（静岡県伊豆市）
  • Year and Date: 2014-11-12 – 2014-11-14
• [Presentation] リウマチ患者のレントゲン画像における骨間距離の測定とその有用性 (2014)
  • Author(s): 清水雅人,後藤富朗,平野智,桜井優,舟橋康治
  • Organizer: 映像情報メディア学会年次大会
  • Place of Presentation: 大阪大学(大阪府大阪市）
  • Year and Date: 2014-08-31 – 2014-09-02
• [Patent(Industrial Property Rights)] 骨間距離測定装置、骨間距離測定方法、コンピュータを骨間距離測定装置として機能させるためのプログラム及び該プログラムを記憶した記録媒体 (2015)
  • Inventor(s): 舟橋康治,後藤富朗,清水雅人
  • Industrial Property Rights Holder: 名古屋大学
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2015-022533
  • Filing Date: 2015-02-06