| Project/Area Number |
25861312
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Mie University |
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Principal Investigator |
KOKUBU Naoki 三重大学, 医学部附属病院, 助教 (40632378)
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| Co-Investigator(Renkei-kenkyūsha) |
TUJII Masaya 三重大学, 医学系研究科, 助教 (40444442)
IINO Takahiro 三重大学, 医学系研究科, 技術補佐員 (80626119)
SUDO Akihiro 三重大学, 医学系研究科, 教授 (60196904)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | BMP / 末梢神経再生 / Schwann cell |
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| Outline of Final Research Achievements |
The peripheral nerve injury made the significant up-regulation of BMP7/Smad signaling in the axon-Schwann cell units at the distal to the injured site. in vitro study demonstrated that cell viability of Schwann Cells(SCs) was significantly increased by administration of BMP7. Also by PTH(1-34) administration, electrophysiological studies showed the advantage of improvement of MCV after peripheral nerve injury. Furthermore, in vitro study, the Expression of BMP7 in SCs was significantly increased by administration of PTH(1-34).From these results, re-expressed BMP7/Smad signal can indirectly function in axonal regeneration as a neurotrophic growth factor for SCs, and suggested that PTH(1-34) is not only acting on bone metabolism, and is involved in peripheral nerve regeneration through SCs.
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