Effect of intermittent administration of teriparatide on bone morphogentic protein-induced bone formation in a rat model of spinal fusion
| Project/Area Number |
25861313
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Osaka University |
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Principal Investigator |
Kaito Takashi 大阪大学, 医学(系)研究科(研究院), 助教 (70623982)
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| Research Collaborator |
MORIMOTO Tokimitsu
KANAYAMA Sadaaki
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | BMP / Teriparatide / Bone regeneratoin / Spinal fusion / Remodeling / Modeling / bone regeneration / PTH1-34 / spinal fusion / remodeling |
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| Outline of Final Research Achievements |
Although clinical bone morphogentic protein (BMP) therapy is effective, but the required doses are very high. Teriparatide (PTH1-34)is a potent anabolic agent for the treatment of osteoporosis. In the studies, intermittent administration of PTH 1-34 combinedwith BMP transplantation was performed. PTH1-34 administration significantly increased fusion rates and quality of the neuwly formed bone. In addition modeling effect on the excessively induced new bone was observed by the administration of PTH1-34. Bone morphohistometry demonstrated predominat bone formation at endosteum and predominat bone resorption at periosteum. The activation of Wnt signaling and PTH receptor at osteocyte by PTH 1-34 might played a role. Our results suggest that the combined administration BMP and PTH1-34 may enalbe efficinet bone regeneration in the clinical setting.
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Report
(4 results)
Research Products
(16 results)
