| Project/Area Number |
25861316
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Orthopaedic surgery
|
|---|
| Research Institution | Shimane University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
|
|---|
| Keywords | 変形性関節症 / 関節軟骨 / コラーゲンネットワーク / リジルオキシダーゼ / コラーゲンクロスリンク |
|---|
| Outline of Final Research Achievements |
Construction of the collagen network (collagen crosslink) is important to maintain the function of articular cartilage. Formation of the collagen crosslink is related to lysyl oxydase (LOX). In osteoarthritis, the change of LOX and crosslink is unclear. The association between crosslink and mechanical property of cartilage is unclear.
I investigated the association between crosslink and osteoarthritis with the Japanese white rabbits. Content of GAG in the cartilage decreased with progress of the cartilage degeneration. On the other hand, the change of crosslink was not significant. Viscoelasticity of the degenerated cartilage decreased with progress of the cartilage degeneration. It did not have relation between viscoelasticity and quantity of crosslink.
|
