| Project/Area Number |
25861330
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 関節病学 / 特発性大腿骨頭壊死症 / ステロイド / アルコール / 動物モデル / 予防 |
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| Outline of Final Research Achievements |
Effective prevention strategy for osteonecrosis of the femoral head (ONFH) was not established. In the present study, we hypothesized that lansoprazole has a potent to suppress IRF7 activity through the inhibition of endosome function, and that lansoprazole could prevent ONFH in rats and in patients with immune diseases treated with corticosteroid. As a result, co-treatment of lansoprazole with corticosteroid significantly repressed IRF7 activity in rats, and significantly prevented developing ONFH in rats. And, the incidence of ONFH in the lansopazole treated group was significantly lower from that in the Alcohol group.
As described above, we observed that lansoprazole has a potent to prevent developing ONFH in rats. Thus, we conducted a preliminary clinical trail.
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