| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Outline of Final Research Achievements |
Aging is one of risk factors for the articular cartilage disorder known as osteoarthritis. It is generally accepted that collagen hydrolysate (CH) supplements ameliorate aging-induced osteoarthritis. The purpose of this study was to explore gene markers for an effective solution to treat osteoarthritis by using transcriptome analysis of chondrocyte cell lines supplemented with CH.
Gene ontology analysis indicated a new candidate gene, protein kinase C zeta (PKC zeta), for the differentiation of chondrocytes. The mRNA levels of PKC zeta in the transcriptome analysis were suppressed by CH. Our findings suggest that PKC zeta may be a candidate age-promoting factor in articular cartilage and that CH could suppress PKC zeta expression to prevent aging of articular cartilage.
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