Proteomic analyses of bone and soft tissue tumors

• Project/Area Number: 25861342
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Orthopaedic surgery
• Research Institution: Juntendo University
• Principal Investigator: Suehara Yoshiyuki 順天堂大学, 医学部, 准教授 (70509405)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 骨軟部腫瘍 / タンパク質発現解析 / プロテオミクス / GIST / 滑膜肉腫 / Ewing肉腫 / 横紋筋肉腫 / KTCD12

Outline of Final Research Achievements

We conducted proteomics analyses to generate the protein profiles regarding bone and soft-tissue tumors (BST) and discover novel biomarkers of BST. We performed validation and functional studies for identified proteins that were candidate biomarkers. In this project, we focused on GIST, Ewing sarcoma, synovial sarcoma, osteosarcoma as well as epithelioid sarcoma In the results, we identified several proteins which were candidates of biomarkers including prognosis and chemo-sensitivities. We also succeeded to validate the power of biomarker in the each larger cohort as validation studies. And we succeeded to elucidate functions regarding malignancies and chemo-resistances as functional studies. Furthermore, we conducted proteomics analyses to generate the protein profiles regarding histological specific fusion genes in BST.

Research Products

• [Journal Article] The Recognition of Locomotive Syndrome in 2014: A Cross-sectional Study in the Orthopeadic Outpatients in Tokyo. (2015)
  • Author(s): Ishii M, Kim Y, Suehara Y, Kawasaki T, Matsuoka J, Akaike K, Mukaihara K, Kubota D, Okubo T, Saito T, Takagi T, Kaneko K.
  • Journal Title: British Journal of Medicine & Medical Research Volume: 6(6) Issue: 6 Pages: 606-616
  • DOI: 10.9734/bjmmr/2015/14207
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Sarcomatous transformation of EGFR and TP53 mutation-positive metastatic adenocarcinoma of the lungs, masquerading as a primary pleomorphic sarcoma of the proximal femur (2015)
  • Author(s): Toda-Ishii M, Akaike K, Kurisaki-Arakawa A, Arakawa A, Mukaihara K, Suehara Y, Takagi T, Kaneko K, Yao T, Saito T.
  • Journal Title: International journal of clinical and experimental pathology. Volume: 8 Pages: 3270-3278
  • Peer Reviewed / Open Access
• [Journal Article] Spindle cell lipoma of the wrist, occurring in a distinctly rare location: a case report with review of literature. (2015)
  • Author(s): Akaike K, Suehara Y, Takagi T, Kaneko K, Yamashita A, Yao T, Saito T.
  • Journal Title: International journal of clinical and experimental pathology. Volume: 8 Pages: 3299-3303
  • Peer Reviewed / Open Access
• [Journal Article] Distinct clinicopathologic features of NAB2-STAT6 fusion gene variants in solitary fibrous tumor with emphasis on the acquisition of highly malignant potential. (2014)
  • Author(s): Akaike K, Kurisaki-Arakawa A, Hara K, Suehara Y, Takagi T, Mitani K, Kaneko K, Yao T, Saito T.
  • Journal Title: Hum Pathol. Volume: 46(3) Issue: 3 Pages: 347-356
  • DOI: 10.1016/j.humpath.2014.11.018
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Rationale for co-targeting IGF-1R and ALK in ALK fusion positive lung cancer (2014)
  • Author(s): 4.Lovly CM, McDonald NT, Chen H, Jin H, Lim D, Suehara Y, Wang Lu, Chen X, Lu P, Red-Brewer M, Johnson DH, Horn L, Ladanyi M, Pao W
  • Journal Title: Nature Medicine Volume: 20(9) Issue: 9 Pages: 1027-1034
  • DOI: 10.1038/nm.3667
  • Peer Reviewed
• [Journal Article] Proteomic Profile of Epithelioid Sarcoma (2014)
  • Author(s): Mukaihara K, Kubota D, Yoshida A, Asano N, Suehara Y, Kaneko K, Kawai A, Kondo T
  • Journal Title: Journal of Proteomics & Bioinformatics Volume: 7 Issue: 07 Pages: 158-165
  • DOI: 10.4172/jpb.1000316
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] A case of low-grade fibromyxoid sarcoma with unusual central necrosis in a 77-year-old man confirmed by FUS-CREB3L2 gene fusion. (2014)
  • Author(s): Kurisaki-Arakawa A, Akaike K, Tomomasa R, Arakawa A, Suehara Y, Takagi T, Kaneko K, Yao T, Saito T.
  • Journal Title: International Journal of Surgery Case Reports. Volume: 5(12) Issue: 12 Pages: 1123-1127
  • DOI: 10.1016/j.ijscr.2014.09.034
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Deeply located low-grade fibromyxoid sarcoma with FUS-CREB3L2 gene fusion in a 5-year-old boy with review of literature (2014)
  • Author(s): Kurisaki-Arakawa A, Suehara Y, Arakawa A, Takagi T, Takahashi M, Mitani K, Kaneko K, Yao T, Saito T.
  • Journal Title: Diagn Pathol Volume: 9(1) Issue: 1 Pages: 163-163
  • DOI: 10.1186/1749-799x-6-15
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] A case of primary spindle cell variant of embryonal rhabdomyosarcoma of the prostate. (2014)
  • Author(s): Asahina M, Saito T, Arakawa A, Suehara Y, Takagi T, Hisasue S, Kaneko K, Horie S, Yao T.
  • Journal Title: Int J Clin Exp Pathol Volume: 7(8) Pages: 5181-5185
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Eggshell-like mineralized recurrent lesion in the popliteal region after treatment of giant cell tumor of bone with denosumab (2014)
  • Author(s): Akaike K, Suehara Y, Takagi T, Kaneko K, Saito T.
  • Journal Title: Skeletal Radiol Volume: 43(12) Issue: 12 Pages: 1767-1772
  • DOI: 10.1007/s00256-014-1961-z
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Giant-cell tumor of bone arising in the anterior rib with a positive expression of GPX-1: a case report and review of the literature. (2014)
  • Author(s): oda M, Suehara Y, Akaike K, Okubo T, Kubota D, Mukaihara K, Kaneko K, Yao T, Takagi T, Saito T.
  • Journal Title: Int Canc Conf J Volume: 3 Issue: 3 Pages: 178-182
  • DOI: 10.1007/s13691-013-0142-6
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Pfetin as a risk factor of recurrence in gastrointestinal stromal tumors (2014)
  • Author(s): Orita H, Ito T, Sakurada M, Kushida T, Maekawa H, Wada R, Suehara Y, Kubota D, and Sato K.
  • Journal Title: BioMed Research International Volume: 651935 Pages: 1-4
  • DOI: 10.1155/2014/651935
  • Peer Reviewed / Open Access
• [Journal Article] Proteomic approach to gastrointestinal stromal tumor identified prognostic biomarkers (2014)
  • Author(s): Kubota T, Yoshida A, Kikuta K, Saito T, Suehara Y, Gotoh M, Kawai A, Kondo T.
  • Journal Title: Journal of Proteomics & Bioinformatics Volume: 7(1) Issue: 01 Pages: 10-16
  • DOI: 10.4172/jpb.1000297
  • Peer Reviewed / Open Access
• [Journal Article] An Outpatient-based Survey about the Recognition of Locomotive Syndrome and the Results of the Loco-check at a University Hospital in Tokyo (2014)
  • Author(s): Okubo T, Suehara Y, Kawasaki T, Akaike K, Toda M, Okubo N, Kubota D, Mukaihara K, Kim Y, Kaketa T, Homma Y, Shimanouchi N, Saito T, Takagi T and Kaneko K.
  • Journal Title: British Journal of Medicine & Medical Research Volume: 4(17) Issue: 17 Pages: 3255-3268
  • DOI: 10.9734/bjmmr/2014/7506
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Quantitative assessment of intragenic receptor tyrosine kinase deletions in primary glioblastomas: their prevalence and molecular correlates (2013)
  • Author(s): Kastenhuber ER, Huse JT, Berman SH, Pedraza A, Zhang J, Suehara Y, Viale A, Cavatore M, Heguy A, Szerlip N, Ladanyi M, Brennan CW
  • Journal Title: Acta Neuropathologica Volume: - Issue: 5 Pages: 747-759
  • DOI: 10.1007/s00401-013-1217-3
  • Peer Reviewed
• [Journal Article] Tissue Sample Preparation for Biomarker Discovery (2013)
  • Author(s): Suehara Y, Kubota D, Saito T
  • Journal Title: Methods in Molecular Biology Volume: 1002 Pages: 13-23
  • DOI: 10.1007/978-1-62703-360-2_2
  • ISBN: 9781627033596, 9781627033602
  • Peer Reviewed
• [Journal Article] Proteomic technologies to develop biomarkers and functional analyses for bone and soft tissue tumors (2013)
  • Author(s): Suehara Y, Kohsaka S, Kubota D, Mukaihara K, Akaike K, Mineki R, Fujimura T , Kaneko K, Ladanyi M, Saito T, Kondo T
  • Journal Title: Journal of Proteomics & Bioinformatics Volume: S3 Pages: 1-1
  • DOI: 10.4172/jpb.s3-001
  • Peer Reviewed
• [Journal Article] Response to Cabozantinib in Patients with RET Fusion-Positive Lung Adenocarcinomas (2013)
  • Author(s): Drilon A, Wang L, Hasanovic A, Suehara Y, Lipson D, Stephens P, Ross J, Miller V, Ginsberg M, Zakowski MF, Kris MG, Ladanyi M, Rizvi N
  • Journal Title: Cancer Discovery Volume: 3 Issue: 6 Pages: 630-5
  • DOI: 10.1158/2159-8290.cd-13-0035
  • Peer Reviewed
• [Journal Article] Gene expression network analysis of ETV1 reveals KCTD10 as a novel prognostic biomarker in gastrointestinal stromal tumor. (2013)
  • Author(s): Kubota D, Yoshida A, Tsuda H, Suehara Y, Okubo T, Saito T, Orita H, Sato K, Taguchi T, Yao T, Kaneko K, Katai H, Kawai A, Kondo T.
  • Journal Title: PLoS One. Volume: 8 Issue: 8 Pages: e73896-e73896
  • DOI: 10.1371/journal.pone.0073896
  • Peer Reviewed
• [Journal Article] Desmoplastic fibroma of the scapula with fluorodeoxyglucose uptake on positron emission tomography: a case report and literature review (2013)
  • Author(s): Okubo T, Saito T, Takagi T, Torigoe T, Suehara Y, Akaike K, Yao T, Kaneko K
  • Journal Title: Int J Clin Exp Pathol Volume: 15 Pages: 2230-6
  • Peer Reviewed
• [Journal Article] Desmoplastic fibroma of the rib with cystic change : A case report with review of literature. (2013)
  • Author(s): Okubo T, Saito T, Takagi T, Suehara Y, Kaneko K
  • Journal Title: Skeletal Radiol Volume: 43 Issue: 5 Pages: 703-8
  • DOI: 10.1007/s00256-013-1772-7
  • Peer Reviewed
• [Journal Article] Possible involvement of p53 genetic alteration associated with protein overexpression in malignant transformation of giant-cell tumor of bone. (2013)
  • Author(s): Okubo T, Saito T, Mitomi H, Takagi T, Torigoe T, Suehara Y, Yao T, Kaneko K.
  • Journal Title: Virchows Arch Volume: 63 Issue: 1 Pages: 67-77
  • DOI: 10.1007/s00428-013-1435-z
  • Peer Reviewed
• [Journal Article] The prognostic value of pfetin: a validation study in gastrointestinal stromal tumors using a commercially available antibody. (2013)
  • Author(s): Kubota D, Mukaihara K, Yoshida A, Suehara Y, Saito T, Okubo T, Gotoh M, Orita H, Tsuda H, Kaneko K, Kawai A, Kondo T, Sato K, Yao T.
  • Journal Title: Jpn J Clin Oncol. Volume: 43 Issue: 6 Pages: 669-675
  • DOI: 10.1093/jjco/hyt057
  • Peer Reviewed
• [Journal Article] Proteomic approach toward personalized sarcoma treatment : lessons from prognostic biomarker discovery in gastrointestinal stromal tumor (2013)
  • Author(s): Kondo T, Kawai A
  • Journal Title: Proteomics Clin Appl Volume: 7(1-2) Issue: 1-2 Pages: 70-78
  • DOI: 10.1002/prca.201200085
  • Peer Reviewed
• [Presentation] Clinicopathological and functional analyses of protein phosphatase 2, regulatory subunit A, alpha mutations in gastrointestinal stromal cell tumors. (2015)
  • Author(s): Suehara Y, Ishii M, Akaike K, Mukaihara K, Kubota D, Okubo T, Takagi T, Yao T, Kaneko K, Saito T.
  • Organizer: European Society For Medical Oncology - ASAIA
  • Place of Presentation: Singapore
  • Year and Date: 2015-12-18
  • Int'l Joint Research
• [Presentation] Ewing肉腫EWS/FLI1融合遺伝子発現のプロテオミクス解析 (2015)
  • Author(s): 末原 義之, 向井原 健太, 赤池 慶祐, 石井 翠, 高阪 真路, 藤村 努, 高木 辰哉, 金子 和夫, Ladanvi Marc, 齋藤 剛
  • Organizer: 第48回日本整形外科学会・骨軟部腫瘍学術集会
  • Place of Presentation: 高松
  • Year and Date: 2015-07-09
• [Presentation] Clinicopathological impacts of protein phosphatase 2, regulatory subunit A, alpha mutations in gastrointestinal stromal tumors. (2015)
  • Author(s): Ishii M, Suehara Y, Akaike K, Mukaihara K, Kubota D, Okubo T, Takagi T, Yao T, Kaneko K, Saito T.
  • Organizer: American Society of Clinical Oncology Annual Meeting
  • Place of Presentation: Chicago, USA
  • Year and Date: 2015-05-29
  • Int'l Joint Research
• [Presentation] Ewing肉腫EWS/FLI1融合遺伝子発現に関わる網羅的タンパク質発現解析 (2015)
  • Author(s): 末原 義之, 高阪 真路, 向井原 健太, 赤池 慶祐, 石井 翠, 峯木 礼子, 藤村 努, 數野 彩子, 金子 和夫, Ladanyi Marc, 齋藤 剛
  • Organizer: 第88回日本整形外科学会学術総会
  • Place of Presentation: 神戸
  • Year and Date: 2015-05-21
• [Presentation] Proteomic approaches for defining the protein profiles of EWS/FLi1 in Ewing's sarcomas. (2015)
  • Author(s): Suehara Y, Kohsaka S, Mukaihara K, Akaike K, Ishii M, Kubota D, Kazuno S, Mineki R, Fujimura T, Kaneko K, Ladanyi M, Saito T.
  • Organizer: the 61th Annual Meeting of the Orthopaedic Research Society
  • Place of Presentation: Las vegans, USA
  • Year and Date: 2015-03-28 – 2015-03-31
• [Presentation] Distinct Clinicopathologic Features Of Nab2-stat6 Fusion Gene Variants In Solitary Fibrous Tumor With Emphasis On The Acquisition Of Highly Malignant Potential. (2015)
  • Author(s): Akaike K, Kurisaki-Arakawa A, Hara K, Suehara Y, Takagi T, Kaneko K, Yao T, Saito T.
  • Organizer: the 61th Annual Meeting of the Orthopaedic Research Society
  • Place of Presentation: Las vegans, USA
  • Year and Date: 2015-03-28 – 2015-03-31
• [Presentation] Proteomic identified overexpression of SET nuclear oncogene products and possible therapeutic target in alveolar soft part sarcoma. (2014)
  • Author(s): Kubota D, Mukaihara K, Suehara Y, Yoshida A, Kaneko K, Kawai A, Kondo T
  • Organizer: Connective Tissue Oncology Society, 2014 Annual Meeting
  • Place of Presentation: Berlin, Germany
  • Year and Date: 2014-10-15 – 2014-10-18
• [Presentation] Functional analysis of F-actin capping protein subunit beta in epithelioid sarcomas. (2014)
  • Author(s): Mukaihara K, Kubota D, Suehara Y, Akaike K, Ishii M, Kohsaka S, Kaneko K, SaitO T
  • Organizer: Connective Tissue Oncology Society, 2014 Annual Meeting
  • Place of Presentation: Berlin, Germany
  • Year and Date: 2014-10-15 – 2014-10-18
• [Presentation] Protein expression profiling of giant cell tumors of bone treated with denosumab. (2014)
  • Author(s): Mukaihara K, Suehara Y, Kubota D, Akaike K, Ishii M, Kohsaka S, Kaneko K, Saito T
  • Organizer: Connective Tissue Oncology Society, 2014 Annual Meeting
  • Place of Presentation: Berlin, Germany
  • Year and Date: 2014-10-15 – 2014-10-18
• [Presentation] Proteomic approaches for defining the protein profiles of EWS/FLi1 in patients with Ewing's sarcoma. (2014)
  • Author(s): Suehara Y, Kohsaka S, Mukaihara K, Kubota D, Akaike K, Ishii M, Kazuno S, Mineki R, Fujimura T, Kaneko K, Ladanyi M, Saito T
  • Organizer: Connective Tissue Oncology Society, 2014 Annual Meeting
  • Place of Presentation: Berlin, Germany
  • Year and Date: 2014-10-15 – 2014-10-18
• [Presentation] 骨軟部腫瘍の「治療手がかり」の探索を目的とした網羅的な解析ータンパク質発現, 遺伝子変異, チロシンキナーゼ標的よりー (2014)
  • Author(s): 末原義之
  • Organizer: 第29回日本整形外科学会・基礎学術集会
  • Place of Presentation: 鹿児島（城山観光ホテル）
  • Year and Date: 2014-10-09 – 2014-10-10
  • Invited
• [Presentation] 骨軟部腫瘍のプロテオーム解析 (2014)
  • Author(s): 末原義之
  • Organizer: 第73回日本癌学会
  • Place of Presentation: 横浜（パシフィコ横浜）
  • Year and Date: 2014-09-25 – 2014-09-27
  • Invited
• [Presentation] 網羅的発現解析による骨軟部腫瘍の「治療手がかり」の探索 (2014)
  • Author(s): 末原義之
  • Organizer: 第３回回文京整形外科合同セミナー
  • Place of Presentation: 東京（御茶ノ水ソラシティカンファレンスセンター）
  • Year and Date: 2014-07-29
  • Invited
• [Presentation] 分子標的治療薬の時代へ；Ewing’s 肉腫におけるEWS/FLI1融合遺伝子のi-TRAQ解析（プロテオーム解析 (2014)
  • Author(s): 末原義之
  • Organizer: 第47回日本整形外科学会・骨軟部腫瘍学術集会
  • Place of Presentation: 大阪（大阪国際会議場）
  • Year and Date: 2014-07-17 – 2014-07-18
  • Invited
• [Presentation] Ewing’s 肉腫におけるNucleophosminの遺伝子発現ベースの機能解析 (2014)
  • Author(s): 末原義之,高阪真路, Neerav Shukla,窪田大介,金子和夫, Marc Ladanyi,齋藤剛
  • Organizer: 第47回日本整形外科学会・骨軟部腫瘍学術集会
  • Place of Presentation: 大阪（大阪国際会議場）
  • Year and Date: 2014-07-17 – 2014-07-18
• [Presentation] Ewing’s 肉腫におけるNucleophosminのプロテオミクスベースの機能解析 (2014)
  • Author(s): 末原義之,高阪真路, Neerav Shukla,窪田大介,峯木礼子,藤村努,金子和夫, Marc Ladanyi,齋藤剛
  • Organizer: 第47回日本整形外科学会・骨軟部腫瘍学術集会
  • Place of Presentation: 大阪（大阪国際会議場）
  • Year and Date: 2014-07-17 – 2014-07-18
• [Presentation] 骨軟部肉腫のチロシンキナーゼ融合遺伝子の探索のためのNanoString解析 (2014)
  • Author(s): 末原義之, Marc Ladanyi
  • Organizer: 第87回日本整形外科学会学術総会
  • Place of Presentation: 神戸（国際会議場 ポートピアホール ）
  • Year and Date: 2014-05-22 – 2014-05-25
• [Presentation] Proteomic approaches for evaluating functions of nucleophosmin in Ewing's sarcomas. (2014)
  • Author(s): Suehara Y, Kohsaka K , Shukla N, Kubota D, Mineki R, Fujimura T, Saito T, Ladanyi M
  • Organizer: 10th Asia Pacific Musculoskeletal Tumour Society (APMSTS)
  • Place of Presentation: Melbourne, Australia
  • Year and Date: 2014-04-09 – 2014-04-11
• [Presentation] Proteomic approaches for evaluating functions of nucleophosmin in Ewing's sarcomas. (2014)
  • Author(s): Suehara Y, Kohsaka K , Shukla N, Kubota D, Mineki R, Fujimura T, Saito T, Ladanyi M
  • Organizer: the 60th Annual Meeting of the Orthopaedic Research Society
  • Place of Presentation: New Orleans, USA
• [Presentation] Nucleophosmin expression defines a more aggressive subset of Ewing’s sarcoma. (2013)
  • Author(s): Suehara Y, Kohsaka S, Shukla N, Ito T, Nafa K, Ladanyi M
  • Organizer: Connective Tissue Oncology Society
  • Place of Presentation: New York, USA
• [Presentation] 骨肉腫のプロテオーム解析 (2013)
  • Author(s): 末原義之
  • Organizer: 第46回日本整形外科学会骨軟部腫瘍学術集会
  • Place of Presentation: 東京
• [Presentation] 肺腺癌新規チロシンキナーゼ融合遺伝子の探索とRET融合遺伝子のXL184第II相臨床試験 (2013)
  • Author(s): 末原義之
  • Organizer: プレナリーセッション＿第51回日本癌治療学会学術集会
  • Place of Presentation: 京都
  • Invited
• [Presentation] 新規骨軟部腫瘍治療標的の開発を目的としたチロシンキナーゼ融合遺伝子の探索 -Memorial Sloan Kettering Cancer Center, NYの経験より- (2013)
  • Author(s): 末原義之
  • Organizer: 第10回関東骨軟部基礎を語る会
  • Place of Presentation: 東京
  • Invited
• [Presentation] Discovery of novel therapy target in sarcomas and cancers by a systematic screen for tyrosine kinase fusions (2013)
  • Author(s): 末原義之
  • Organizer: 関東骨軟部腫瘍研究会
  • Place of Presentation: 東京医科歯科大学
  • Invited
• [Presentation] 新規tyrosine kinase治療標的の開発を目的としたNanoString解析 -Memorial Sloan Kettering Cancer Centerにおける肺癌_RET fusionの臨床応用に向けた動き- (2013)
  • Author(s): 3. 末原義之
  • Organizer: 順天堂大学：がん学アカテミア
  • Place of Presentation: 順天堂大学
  • Invited
• [Presentation] Discovery of tyrosine kinase fusions in lung adenocarcinomas and phase 2 trial of the RET inhibitor XL184 (2013)
  • Author(s): Yoshiyuki Suehara, Maria E. Arcila , Lu Wang, Adnan Hasanovic, Alexander Drilon, Raya Khanin, Mark G. Kris, Maureen F. Zakowski, Naiyer Rizvi, and Marc Ladanyi
  • Organizer: 第72回日本癌学会学術集会
  • Place of Presentation: 横浜
• [Presentation] 骨軟部腫瘍の新規治療ターゲットの開発を目的としたNanoString解析 (2013)
  • Author(s): 末原義之, Marc Ladanyi
  • Organizer: 第28回日本整形外科学会基礎学術集会
  • Place of Presentation: 千葉
• [Presentation] シンポジウム：ゲノムビッグデータとバイオインフォマティクス 新たな創薬へ 新たな創薬へ 骨・軟部腫瘍の新規治療法開発を目的としたプロテオーム解析
  • Author(s): 1.末原 義之, 向井原 健太, 窪田 大介, 赤池 慶祐, 石井 翠, 高阪 真路, 藤村 努, 金子 和夫, Ladanyi Marc, 齋藤 剛
  • Organizer: 第30回日本整形外科学会・基礎学術集会
  • Place of Presentation: 富山
  • Invited