| Project/Area Number |
25861342
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 骨軟部腫瘍 / タンパク質発現解析 / プロテオミクス / GIST / 滑膜肉腫 / Ewing肉腫 / 横紋筋肉腫 / KTCD12 |
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| Outline of Final Research Achievements |
We conducted proteomics analyses to generate the protein profiles regarding bone and soft-tissue tumors (BST) and discover novel biomarkers of BST. We performed validation and functional studies for identified proteins that were candidate biomarkers. In this project, we focused on GIST, Ewing sarcoma, synovial sarcoma, osteosarcoma as well as epithelioid sarcoma In the results, we identified several proteins which were candidates of biomarkers including prognosis and chemo-sensitivities. We also succeeded to validate the power of biomarker in the each larger cohort as validation studies. And we succeeded to elucidate functions regarding malignancies and chemo-resistances as functional studies. Furthermore, we conducted proteomics analyses to generate the protein profiles regarding histological specific fusion genes in BST.
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