Analysis of cerebrospinal fluid biomarkers in acutely worsening symptoms of compression myelopathy
Project/Area Number |
25861346
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Orthopaedic surgery
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Research Institution | Toho University |
Principal Investigator |
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Project Period (FY) |
2013-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | biomarker / compression myelopathy / cerebrospinal fluid / pNF-H / reversible axonal damage |
Outline of Final Research Achievements |
To our knowledge, there is no report that analyzed the various biomarkers of cerebrospinal fluid (CSF) that evaluate degree of damage to axon, astrocytes, and Schwann cells. Therefore, we determined levels of biomarkers reflecting damage to these cells in the CSF of patients with worsening symptoms of cervical compression myelopathy. We collected 69 samples of CSF from patients before spinal surgery for acutely worsening compression myelopathy (AM, 20), chronic compression myelopathy (CM, 20), and lumbar canal stenosis (LCS; control group 29). As the result, significantly higher levels of pNF-H and Tau that reflect axonal damage were detected in the CSF of patients with AM compared with those in either CM or LCS group. On the other hands, the level of MBP, S100b, and NSE were not significantly different between the three groups. The present results suggest that axonal damage is remarkable compared with demyelination, astrocytic, and neuronal damage in AM.
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Report
(5 results)
Research Products
(52 results)
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[Journal Article] Less invasive lumbopelvic fixation technique using a percutaneous pedicle screw system for unstable pelvic ring fracture in a patient with severe multiple traumas.2017
Author(s)
Yano S, Aoki Y, Watanabe A, Nakajima T, Takazawa M, Hirasawa H, Takahashi K, Nakagawa K, Nakajima A, Takahashi H, Orita S, Eguchi Y, Suzuki T, Ohtori S.
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Journal Title
J neurosurg Spine
Volume: 26
Issue: 2
Pages: 203-207
DOI
Related Report
Peer Reviewed
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[Journal Article] Transplanted peripheral blood stem cells mibilized by granulocyte colony-stimulating factor promoted hindlimb functional recovery after spinal cord injury in mice2016
Author(s)
Takahashi H, Koda M, Hashimoto M, Furuya T, Sakuma T, Kato K, Okawa A, Inada T, Kamiya K, Ota M, Maki S, Takahashi K, Yamazaki M, Mannoji C.
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Journal Title
Cell Transplantation
Volume: 25
Issue: 2
Pages: 283-92
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Granulocyte colony-stimulating factor attenuates spinal cord injury-induced mechanical allodynia in adult rats.2015
Author(s)
Kato K, Koda M, Takahashi H, Sakuma T, Inada T, Kamiya K, Ota M, Maki S, Okawa A, Takahashi K, Yamazaki M, Aramomi M, Hashimoto M, Ikeda O, Mannoji C, Furuya T.
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Journal Title
J Neurol Sci
Volume: 355
Issue: 1-2
Pages: 79-83
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Neuroprotective therapy with granulocyte colony-stimulating factor in acute spinal cord injury: a comparison with high-dose methylprednisolone as a historical control2015
Author(s)
Kamiya K, Koda M, Furuya T, Kato K, Takahashi H, Sakuma T, Inada T, Ota M, Maki S, Okawa A, Ito Y, Takahashi K, Yamazaki M.
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Journal Title
Eur Spine J
Volume: 24
Issue: 5
Pages: 963-7
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Influence of pelvic incidence-lumbar lordosis mismatch on surgical outcomes of short-segment transforaminal lumbar interbody fusion.2015
Author(s)
Aoki Y, Nakajima A, Takahashi H, Sonobe M, Terajima F, Saito M, Takahashi K, Ohtori S, Watanabe A, Nakajima T, Takazawa M, Orita S, Eguchi Y, Nakagawa K.
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Journal Title
BMC Musculoskelet Disord
Volume: 16
Issue: 1
Pages: 213-213
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Phosphorylated neurofilament subunit NF-H becomes elevated in the cerebrospinal fluid of patients with acutely worsening symptoms of compression myelopathy: a pilot cross-sectional study in humans.2014
Author(s)
Takahashi H, Aoki Y, Nakajima A, Sonobe M, Terajima F, Saito M, Taniguchi S, Yamada M, Watanabe F, Furuya T, Koda M, Yamazaki M, Takahashi K, Nakagawa K.
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Journal Title
Journal of Clinical Neuroscience
Volume: 21
Pages: 2175-8
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Increase of nerve growth factor levels in the human herniated intervertebral disc: can annular rupture trigger discogenic back pain?2014
Author(s)
Aoki Y, Nakajima A, Ohtori S, Takahashi H, Watanabe F, Sonobe M, Terajima F, Saito M, Takahashi K, Toyone T, Watanabe A, Nakajima T, Takazawa M, Nakagawa K.
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Journal Title
Arthritis Research Theraphy
Volume: 16
Related Report
Peer Reviewed / Open Access
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[Journal Article] Multicenter prospective nonrandomized controlled clinical trial to prove neurotherapeutic effects of granulocyte colony-stimulating factor for acute spinal cord injury.2014
Author(s)
Inada T, Takahashi H, Yamazaki M, Okawa A, Sakuma T, Kato K, Hashimoto M, Hayashi K, Furuya T, Fujiyoshi T, Kawabe J, Mannoji C, Miyashita T, Kadota R, Someya Y, Ikeda O, Hashimoto M, Suda K, Kajino T, Ueda H, Ito Y, Ueta T, Hanaoka H, Takahashi K, Koda M.
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Journal Title
Spine
Volume: 39
Pages: 213-219
Related Report
Peer Reviewed
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[Presentation] Reversible axonal damage is remarkable in patients with acutely worsening symptoms of compression myelopathy: analysis of human cerebrospinal fluid samples2016
Author(s)
Takahashi H, Aoki Y, Nakajima A, Sonobe M, Terajima F, Saito M, Inoue M, Koyama K, Yamamoto K, Nakagawa K.
Organizer
Eurospine 2016
Place of Presentation
Berlin, Germany
Year and Date
2016-10-06
Related Report
Int'l Joint Research
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[Presentation] Delayed surgical site infection after cervical posterior decompression and fusion in patient with atopic dermatitis, a case report2016
Author(s)
Takahashi H, Aoki Y, Nakajima A, Terajima F, Sonobe M, Saito M, Inoue M, Taniguchi S, Yamada M, Koyama K, Yamamoto K, Nakagawa K.
Organizer
7th annual meeting of Cervical Spine Research Society Asia Pacific Section
Place of Presentation
Seoul, Korea
Year and Date
2016-04-21
Related Report
Int'l Joint Research
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[Presentation] Dropped head syndrome with cervical spondylotic amyotrophy; a case report.2015
Author(s)
Takahashi H, Aoki Y, Nakajima A, Terajima F, Sonobe M, Saito M, Taniguchi S, Yamada M, Nakagawa K.
Organizer
6th Annual Meeting, Cervical Spine Research Society Asia Pacific Section.
Place of Presentation
PACIFICO Yokohama, Yokohamashi, Kanagawa, Japan
Year and Date
2015-03-27 – 2015-03-28
Related Report
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[Presentation] Phosphorylated neurofilament subunit NF-H in the cerebrospinal fluid becomes elevated in patients with acutely worsening symptoms of compression myelopathy: a pilot cross-sectional study in humans.2014
Author(s)
Takahashi H, Aoki Y, Nakajima A, Sonobe M, Terajima F, Saito M, Taniguchi S, Yamada M, Nakagawa K.
Organizer
30 Annual Meeting, Cervical Spine Research Society European Section.
Place of Presentation
Pamplona, Spain
Year and Date
2014-06-25 – 2014-06-27
Related Report
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[Presentation] Phosphorylated neurofilament subunit NF-H in the cerebrospinal fluid becomes elevated in patients with acutely worsening symptoms of compression myelopathy: a human pilot study.2014
Author(s)
akahashi H, Aoki Y, Nakajima A, Sonobe M, Terajima F, Saito M, Taniguchi S, Yamada M, Furuya T, Koda M, Yamazaki M, Takahashi K, Nakagawa K.
Organizer
5th Annual Meeting, Cervical Spine Research Society Asia Pacific Section.
Place of Presentation
Ho Chi Minh, Viet Nam
Year and Date
2014-04-03
Related Report
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