| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
In this study, for evaluation of allodynia, we would conduct fMRI using stimulus of 2000Hz to the two sorts of allodynia model mouse that was surgical procedure model and genetical model.The stimulation of 2,000Hz to healthy mice elicited activation only in contralateral S1, whereas the stimulation to neuropathic pain model mice elicited activation in ACC, thalamus besides S1. For the measurement of normal mice, BOLD activation was observed only in S1. On the other hand, for the measurement of knockout mouse, BOLD activation was observed in ACC and thalamus in addition to S1.
Their brain activities with stimulus were observed and difference of activities in ACC was detected. Precise method of stimulus enables to conduct objective evaluation. Establishment of novel pain evaluation tool by fMRI would contribute to realization of regenerative medicine for neuropahic pain.
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