The alpha7 nicotinic acetylcholine receptor agonist GTS-21 enhances skeletal muscle differentiation and hypertrophy in C2C12.
| Project/Area Number |
25861352
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Anesthesiology
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
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| Research Collaborator |
IWASAKI Hajime 旭川医科大学, 医学部, 助教 (00599368)
Jeevendra Martyn ハーバード大学, 医学部, 教授
INAGAKI Yasuyoshi 旭川医科大学, 医学部, 助教 (90516949)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | アセチルコリン受容体 / 神経筋接合部 / 筋肥大 / 筋分化 / 周術期管理学 / 萎縮筋 |
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| Outline of Final Research Achievements |
Alpha7 nicotinic acetylcholine receptors (a7 nAChRs) have been found in muscle during development and denervation. However, the physiological function of a7 nAChRs in muscle is still unclear. We hypothesized that the a7 nAChRs regulates the differentiation of skeletal muscle cells and investigated the impact of a7 nAChRs on C2C12 murine skeletal muscle cells stimulating with GTS21, agonist of a7 nAChRs.The diameter of myotubes at day 6 treated with GTS-21 were significantly wider than control group . The expression of MHC was relatively increased in GTS-21 treatment group at day 6 .The alpha7 nicotinic acetylcholine receptor agonist GTS-21 enhances skeletal muscle differentiation and hypertrophy in C2C12 myoblasts and myotubes.
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Report
(4 results)
Research Products
(1 results)
