The effect of ketamine on natural killer cell cytotoxicity
Project/Area Number |
25861353
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Anesthesiology
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Research Institution | Hirosaki University |
Principal Investigator |
Hidetomo Niwa 弘前大学, 医学部附属病院, 助教 (20374845)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
|
Keywords | ケタミン / グリオーマ / NMDA受容体拮抗薬 / ナチュラルキラー細胞活性 / 抗腫瘍作用 / 腫瘍増殖抑制 / 脳悪性腫瘍 / 麻酔薬ケタミン / natural killer 細胞活性 |
Outline of Final Research Achievements |
ketamine is very familiar with us since it is commonly used in radical surgery as an anesthetic agent. Unfortunately, even basic data on the anti-tumor effects of ketamine is lacking. In the present study, we found that ketamine induced cell death due to apoptosis, which resulted in suppressing the growth of glioma cells. We know that it may be difficult to apply the results of the basic study to human cases. But, in the current clinical practice, ketamine is the only viable anesthetic option among NMDAR antagonists, and it can be used in neurosurgery. Our results suggest that ketamine is an anesthetic candidate providing potential benefit for glioma resection. Our results suggest that ketamine is an anesthetic candidate providing potential benefit for glioma resection.
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Report
(4 results)
Research Products
(4 results)