| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Creation of the drug was not successful and the plan was changed.
We focused on endogenous analgesia in neuropathic pain and revealed that the attenuated endogenous analgesic pathway was restored in neuropathic pain model rats, when the tricyclic antidepressant was administered. Specifically, amitriptyline was intraperitoneally administered for 5 consecutive days after 5 weeks from the creation of a neuropathic pain model, and capsaicin was administered to the rat forepaw at 6 weeks after preparation to evaluate endogenous pain Noxious stimulus induced analgesia (NSIA) was examined. NSIA attenuated after 6 weeks of nerve injury, but recovery of NSIA was observed by amitriptyline administration.
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