| Project/Area Number |
25861361
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Anesthesiology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
Satomoto Maiko 東京医科歯科大学, 医歯(薬)学総合研究科, 助教 (10611551)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 麻酔 / 神経毒 / 学習 / 脳 / セボフフラン / 幼若脳 / 麻酔薬 / アポトーシス / 活性酸素毒 |
|---|
| Outline of Final Research Achievements |
Neonatal exposure to anaesthetics such as sevoflurane has been reported to result in behavioural deficits in rodents. However, while oxidative injury is thought to play an underlying pathological role, the mechanisms of neurotoxicity remain unclear. In the present study, we investigated whether the NADPH oxidase inhibitor apocynin protects against long-term memory impairment produced by neonatal sevoflurane exposure in mice. Apocynin reduces neuronal apoptosis and protects against long-term memory impairment in mice neonatally exposed to sevoflurane by reducing superoxide levels. These findings suggest that NADPH oxidase inhibitors may protect against cognitive dysfunction resulting from neonatal anaesthesia.
Bone marrow derived mesenchymal cells cannot attenuate neurotoxicity induced by sevoflurane in reonatal rat.
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