The effect of anesthetics on proopiomelanocortin gene expression

• Project/Area Number: 25861373
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Anesthesiology
• Research Institution: Kyoto University
• Principal Investigator: MIZOTA Toshiyuki 京都大学, 医学(系)研究科(研究院), 助教 (80596198)
• Co-Investigator(Renkei-kenkyūsha): FUKUDA Kazuhiko (90199224)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: プロオピオメラノコルチン / 下垂体 / 麻酔薬 / プロポフォール

Outline of Final Research Achievements

We examined the effect of intravenous anesthetics on proopiomelanocortin gene expression in pituitary cell lines.
Ketamine or dexmedetomidine did not affect the proopiomelanocortin gene expression. Propofol dose-dependently enhanced the proopiomelanocortin gene expression.