The role of GABAergic tonic inhibition in sustantia gelatinosa neuron of sciatic nerve chronic constriction injury model mice
| Project/Area Number |
25861374
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Anesthesiology
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| Research Institution | Osaka University |
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Principal Investigator |
TAKAHASHI Ayako 大阪大学, 医学(系)研究科(研究院), 助教 (70444544)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 神経障害性疼痛 / ＧＡＢＡＡ受容体 / tonic電流 / 脊髄 / δサブユニット / GABAA受容体 |
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| Outline of Final Research Achievements |
The present study demonstrated that sciatic nerve constriction (CCI) induced the decrease of GABAergic tonic current and GABAARs δ subunit expression in spinal dorsal horn. Improved understanding of GABAARs δ subunit may facilitate development of more effective treatment strategies for neuropathic pain.
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Report
(3 results)
Research Products
(2 results)
