The role of GABAergic tonic inhibition in sustantia gelatinosa neuron of sciatic nerve chronic constriction injury model mice

Research Project

Project/Area Number	25861374
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Anesthesiology
Research Institution	Osaka University
Principal Investigator	TAKAHASHI Ayako 大阪大学, 医学(系)研究科(研究院), 助教 (70444544)
Project Period (FY)	2013-04-01 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000) Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords	神経障害性疼痛 / ＧＡＢＡＡ受容体 / tonic電流 / 脊髄 / δサブユニット / GABAA受容体
Outline of Final Research Achievements	The present study demonstrated that sciatic nerve constriction (CCI) induced the decrease of GABAergic tonic current and GABAARs δ subunit expression in spinal dorsal horn. Improved understanding of GABAARs δ subunit may facilitate development of more effective treatment strategies for neuropathic pain.