The effect of fosaprepitant, meurokinin-1 receptor antagonist, for the prevention of postoperative nausea and vomiting
Project/Area Number |
25861378
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Anesthesiology
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Research Institution | The University of Tokushima |
Principal Investigator |
SOGA Tomohiro 徳島大学, ヘルスバイオサイエンス研究部, 特任助教 (20592538)
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Project Period (FY) |
2013-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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Keywords | 制吐剤 / PONV / ニューロキニン1受容体 / 嘔気 / 嘔吐 / プロイメンドニューロキニン-1 / プロイメンド / ニューロキニン1 |
Outline of Final Research Achievements |
This prospective, double-blind, randomized study comprised patients who underwent abdominal operations. They were randomly allocated to receive intravenous fosaprepitant (NK1) or ondansetron (ONS) before anesthesia. No patient in the NKI group experienced vomiting after surgery; 20-30 % patients in the ONS group experienced vomiting. This difference was significant (at 0-2 h, 2-24 h, 24-48 h, and 48-72 h). During the study period, no significant differences existed between the NK1 and ONS groups in the incidence of PONV, complete response rate, rescue antiemetic use, nausea score, and VAS score for pain. Additionally, NK1 was more effective than ONS in decreasing the incidence of vomiting after lower limb surgery with postoperative opioid administration as well.
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Report
(3 results)
Research Products
(10 results)
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[Journal Article] Fosaprepitant versus ondansetron for the prevention of postoperative nausea and vomiting in patients who undergo gynecologic abdominal surgery with patient-controlled epidural analgesia: a prospective, randomized, double-blind study.2015
Author(s)
Tomohiro Soga, Katsuyoshi Kume, Nami Kakuta, Eisuke Hamaguchi, Rie Tsutsumi, Ryosuke Kawanishi, Kohei Fukuta, Katsuya Tanaka, and Yasuo M. Tsutsumi
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Journal Title
Journal of Anesthesia
Volume: 印刷中
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] A case of placenta percreta with massive hemorrhage during cesarean section2014
Author(s)
Katsuyoshi Kume, Yasuo M. Tsutsumi, Tomohiro Soga, Yoko Sakai, Noriko Kambe, Ryosuke Kawanishi, Eisuke Hamaguchi, Tomiya Kawahara, Asuka Kasai, Yoshimi Nakaji, Youske T. Horikawa, Souichiro Nakayama, Takashi Kaji, Minoru Irahara, and Katsuya Tanaka.
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Journal Title
The Journal of Medical Investigation
Volume: 61
Issue: 1.2
Pages: 208-212
DOI
NAID
ISSN
1343-1420, 1349-6867
Related Report
Peer Reviewed
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[Journal Article] Recent Less-invasive Circulatory Monitoring during Renal Transplantation2013
Author(s)
Soga Tomohiro, Shinji Kawahito, RIe Oi, Nami Kakuta, Toshiko Katayama, Narutomo Wakamatsu, Kazumi Takaishi, Kunihisa Yamaguchi, Hirofumi Izaki, Hiro-omi Kanayama, Hiroshi Kitahata, Shuzo Oshita
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Journal Title
The Journal of Medical Investigation
Volume: 60
Issue: 1.2
Pages: 159-163
DOI
NAID
ISSN
1343-1420, 1349-6867
Related Report
Peer Reviewed
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[Journal Article] Usefulness of central venous oxygen saturation monitoring during bidirectional Glenn shunt2013
Author(s)
Nami Kakuta, Shinji Kawahito, Naoji Mitam Noriko Kambe, Asuka Kasai, Narutomo Wakamatsu, Toshiko Katayama, Tomohiro Soga, Fumihiko Tada, Takashi Kitaichi, Tetsuya Kitagawa Hiroshi Kitahata
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Journal Title
The Journal of Medical Investigation
Volume: 60
Issue: 3.4
Pages: 272-275
DOI
NAID
ISSN
1343-1420, 1349-6867
Related Report
Peer Reviewed
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