Elucidation of the mechanism of the tracheal remodeling in the asthmatic patients with nuclear protein Ki67.

• Project/Area Number: 25861381
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Anesthesiology
• Research Institution: Nagasaki University
• Principal Investigator: ISHII Koji 長崎大学, 病院(医学系), 助教 (40404248)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2013: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: 気管支喘息 / 気道リモデリング / セボフルラン / 喘息 / Ki67

Outline of Final Research Achievements

We made athma model of rats by ovalbumin. With asthma attack, rats volatiled whether oxygen or sevoflurane. After asthma attacks every 2 days for 2weeks, we extracted trachea and lung. we measured the strength of contruction of trackea ring. And we evaluated whether tracheal remodering was established.
We compared the stage of tracheal remodering of each group.