| Project/Area Number |
25861383
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Anesthesiology
|
|---|
| Research Institution | University of the Ryukyus |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2013-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
|---|
| Keywords | Toll様受容体 / 遅発性脊髄障害 / 脊髄虚血 / 遅発性対麻痺 / 神経細胞死 / 自然免疫 |
|---|
| Outline of Final Research Achievements |
We investigated whether TLR4, TLR2, MyD88 or TRIF might be associated withonset of delayed paraplegia after spinal cord ischemia in mice. In our results, either TLR2 KO- or TRIF KO-mice could not show delayed paraplegia. In contrast, both TLR4 KO- and MyD88 KO-mice displayed delayed paraplegia after spinal cord ischemia. These results suggested that either TLR4 or MyD88 should be necessary in onset of delayed paraplegia after spinal cord ischemia.
|
