The effects of intravenous anesthetics and opioids in vivo and in vitro.
Project/Area Number |
25861384
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Anesthesiology
|
Research Institution | Sapporo Medical University |
Principal Investigator |
Iwasaki Soshi 札幌医科大学, 医学部, 講師 (90608910)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
|
Keywords | 静脈麻酔 / 喘息モデル / 静脈麻酔薬 / 吸入麻酔薬 |
Outline of Final Research Achievements |
I had observed the effects of intravenous anesthetics and opioids in vivo and in vitro situations in normal and sensitized guinea pigs,then measured the number of cells in the VAL.In sensitized guinea pigs, the combination of intravenous anesthetics and opioids had strong airway dilation. If there is no combination of opioids, trachea dilating action was attenuated. In the same matter, Eosinophils and neutrophils in the VAL was reduced in combination with opioids . These findings , the total intravenous anesthesia in the real clinical settings, total intravenous anesthesia which showed that indicate the inhalation anesthesia as well airway dilating action.
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Report
(4 results)
Research Products
(4 results)