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The effects of intravenous anesthetics and opioids in vivo and in vitro.

Research Project

Project/Area Number 25861384
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Anesthesiology
Research InstitutionSapporo Medical University

Principal Investigator

Iwasaki Soshi  札幌医科大学, 医学部, 講師 (90608910)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Keywords静脈麻酔 / 喘息モデル / 静脈麻酔薬 / 吸入麻酔薬
Outline of Final Research Achievements

I had observed the effects of intravenous anesthetics and opioids in vivo and in vitro situations in normal and sensitized guinea pigs,then measured the number of cells in the VAL.In sensitized guinea pigs, the combination of intravenous anesthetics and opioids had strong airway dilation. If there is no combination of opioids, trachea dilating action was attenuated. In the same matter, Eosinophils and neutrophils in the VAL was reduced in combination with opioids .
These findings , the total intravenous anesthesia in the real clinical settings, total intravenous anesthesia which showed that indicate the inhalation anesthesia as well airway dilating action.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (4 results)

All 2016 2015

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results) Book (2 results)

  • [Journal Article] Quadratus Lumborum Block: Analgesic Effects and Chronological Ropivacaine Concentrations After Laparoscopic Surgery.2016

    • Author(s)
      Murouchi T, Iwasaki S, Yamakage M
    • Journal Title

      Reg Anesth Pain Med.

      Volume: 2 Issue: 2 Pages: 146-50

    • DOI

      10.1097/aap.0000000000000349

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Chronological changes in ropivacaine concentration and analgesic effects between transversus abdominis plane block and rectus sheath block.2015

    • Author(s)
      Murouchi T, Iwasaki S, Yamakage M
    • Journal Title

      Reg Anesth Pain Med.

      Volume: 40 Issue: 5 Pages: 568-71

    • DOI

      10.1097/aap.0000000000000288

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Book] 気道管理・呼吸器系.麻酔科学文献レビュー2015~2016.2015

    • Author(s)
      岩崎 創史,山蔭 道明
    • Total Pages
      240
    • Publisher
      学研メディカル秀潤社
    • Related Report
      2015 Annual Research Report
  • [Book] 痛みの原因とそのメカニズムからさぐる疼痛治療薬開発の展望.2015

    • Author(s)
      岩崎 創史,杉目 史行,山蔭 道明
    • Total Pages
      580
    • Publisher
      (株)技術情報協会
    • Related Report
      2015 Annual Research Report

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Published: 2014-07-25   Modified: 2019-07-29  

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