Interaction between sugammadex and rocuronium in the septic rat diaphragm

• Project/Area Number: 25861386
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Anesthesiology
• Research Institution: Sapporo Medical University
• Principal Investigator: takahshi kazunobu 札幌医科大学, 医学部, 助教 (40530605)
• Co-Investigator(Renkei-kenkyūsha): NIIYA TOMOHISA 札幌医科大学, 医学部, 講師 (80510312) ; NARIMATU EICHI 札幌医科大学, 医学部, 教授 (70295343)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 筋弛緩薬 / 敗血症 / 重症筋無力症 / スガマデクス / 筋弛緩

Outline of Final Research Achievements

We investigated interactions between sugammadex and rocuronium during reversal of a neuromuscular blockade in sepsis using a rat model of sepsis induced by cecal ligation and puncture. Sepsis attenuates the effects of rocuronium on twitch tension of the rat diaphragm and attenuates the reversal effect of sugammadex and neostigmine on rocuronium-induced depression of train of four ratio and twitch tension in vitro. Additionally, we investigated weather severity of myasthenia gravis affected the relationship between train of four ratio and twitch tension. Severity of myasthenia gravis affects the relationship between train of four ratio and twitch tension, together with changes in run-down of endplate potentials and those around the neuromusculaar junction in rats. Train of four ratio may therefore not be an accurate indicator of recovery from neuromuscular blocking agents in myasthenia gravis patients.

Research Products

• [Journal Article] Severity of Myasthenia Gravis Influences the Relationship between Train-of-four Ratio and Twitch Tension and Run-down of Rat Endplate Potentials. (2016)
  • Author(s): kazunobu takahashi
  • Journal Title: Anesthesiology Volume: 124 Issue: 2 Pages: 369-377
  • DOI: 10.1097/aln.0000000000000949
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] Severity of myasthenia gravis influences the relationship between train of four ratio and twitch tension, and run-down of rat endplate potentials (2015)
  • Author(s): Takahashi K, Takada Y, Niiya T, Narimatsu E, Yamakage M
  • Organizer: The Annual Meeting of the American Society of Anesthesiologists
  • Place of Presentation: San Diego, USA
  • Year and Date: 2015-10-24
  • Int'l Joint Research
• [Presentation] Train of four ratios cannot reflect muscle strength in severe myasthenia gravis: An in vitro study in a rat model of experimental autoimmune myasthenia gravis (2014)
  • Author(s): kazunobu takahashi
  • Organizer: The annual meeting of the American Society of Anesthesiologists
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2014-10-11 – 2014-10-15
• [Presentation] Prospective analysis of sugammadex in 9 patients with myasthenia gravis (2013)
  • Author(s): kazunobu takahashi
  • Organizer: American Society of Anesthesiologists Annual Meeting
  • Place of Presentation: San Francisco
• [Presentation] Minimum levobupivacaine concentration required to block axillary nerves while preserving motor function (2013)
  • Author(s): kazunobu takahashi
  • Organizer: American Society of Anesthesiologists Annual Meeting
  • Place of Presentation: San Francisco
• [Book] 救急集中治療 (2015)
  • Author(s): 高橋和伸， 新谷知久， 成松英智
  • Total Pages: 5
  • Publisher: 総合医学社