| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2015: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
When administering methyl ergometrine maleate which is frequently used during caesarean section operation, attention must be paid to the onset of coronary spasm. However, it is impossible for individual pregnant women to predict the presence or absence of side effects by methyl ergometrine maleate before drug administration. We attempted to elucidate individual differences in expression of side effects by the drug, paying attention to gene single nucleotide polymorphisms of genes expected to be involved in expression of methyl ergometrin maleate effect. We examined the gene single nucleotide polymorphism of patients scheduled for selective caesarean section and analyzed the relation with electrocardiogram ST change. However, the relationship between gene single nucleotide polymorphism and electrocardiogram ST change was not clarified.
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