Does Aquaporin channel have an important role in cancer ascites?

• Project/Area Number: 25861398
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Anesthesiology
• Research Institution: Wakayama Medical University
• Principal Investigator: Toshiyuki Kuriyama 和歌山県立医科大学, 医学部, 講師 (10405467)
• Research Collaborator: Yasuhito Uezono ; Kiyoshi Terawaki
• Project Period (FY): 2013-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: がん性腹水 / アクアポリン / 胃がん細胞 / がん性腹膜炎 / サブセット発現

Outline of Final Research Achievements

Malignant peritonitis is one of the most intractable symptom of abdominal distension for cancer patients and it depends on amount of malignant ascites. However, it remains unclear the mechanism of production of malignant ascites. So we can hardly manage this symptom. We hypothesized that novel water channel "aquaporin" channel might have an important role in production of malignant ascites. The aim of this study was the proof of this hypothesis.
After we implanted 85As2 cells, which is derived from human gastric cancer and induces cancer peritonitis to mice, we observed that severe cancer acsites was observed, but we failed to prove the hypothesis.