Elucidation of the cancer recurrence restraint mechanism of the epidural anesthesia

Research Project

Project/Area Number	25861400
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Anesthesiology
Research Institution	Keio University
Principal Investigator	YAMADA Takashige 慶應義塾大学, 医学部, 助教 (20348767)
Research Collaborator	IGARASHI Toru
Project Period (FY)	2013-04-01 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000) Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000) Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords	硬膜外麻酔 / がん抑制 / Th1/Th2バランス / Th17 / 炎症性サイトカイン / NK活性
Outline of Final Research Achievements	We performed a study to search the change of a cancer recurrence and the perioperative function of immunity, based on the hypothesis ‘Epidural anesthesia maintains the function of natural killer cells and T cells, consequently suppress the cancer multiplication', using the rat long-term epidural anesthesia model which has been already established in our laboratory. We are not able to observe the influence that an epidural anesthesia gave Natural killer cell and T cell in this study. Further studies are warranted to clarify relationship between epidural anesthesia and cancer recurrence.