| Project/Area Number |
25861403
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Anesthesiology
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 神経障害性疼痛 / 抑うつ症状 / 中枢作用 / 不安障害 / 学習障害 / 神経障害性痛 |
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| Outline of Final Research Achievements |
The effects of natural polyphenols on anxiety, depression, and motor performance were examined in rat neuropathic pain models. In chronic constriction injury model and diabetic polyneuropathy model, representative polyphenols, chlorogenic acid, luteolin, and curcumin dose-dependently increased percent of the time spent in the central area and total moving distance in the open field test. They significantly increased time spent in the open arms in the elevated plus maze. They also increased swimming time and decreased immobility time in the forced swim test. On the other hand, they inhibited motor function at highest doses in the rotarod test. These results indicate that chlorogenic acid, luteolin, and curcumin have anxiolytic and antidepressive actions along with antihyperalgesic action in the neuropathic pain models. Natural polyphenols could be candidate therapeutic agents for neuropathic pain.
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