Experimental study of the glycosyltransferase as a drug target of bladder cancer

• Project/Area Number: 25861405
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Urology
• Research Institution: Hirosaki University
• Principal Investigator: Suzuki Yuichiro 弘前大学, 医学研究科, 研究員 (50647344)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
• Keywords: 糖転移酵素 / 糖鎖生物学 / 糖鎖合成阻害 / 分子標的 / siRNA / モノクローナル抗体

Outline of Final Research Achievements

Cell surface carbohydrates expressed on epithelial cells are thought to play an important role in tumor progression.　We previously showed Core2 beta-1,6-N-acetylglucosami-
nyltransferase expression in bladder cancer correlated with tumor progression. In this study, we tryed to inhibit the glycosyltransferase using imitation glucose. The imitation glucose showed specifically inhibition of tumor growth in vitro. Therefore, although further study is necessary to determine the glycosyltransferase as a drug target of cancer, imitation glucose has a potential of novel therapeutic agent.