Identification of perineural invasion related molecule in prostate cancer using phage display screening
Project/Area Number |
25861407
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Urology
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Research Institution | Hirosaki University |
Principal Investigator |
Okamoto Akiko 弘前大学, 医学研究科, 研究員 (60436037)
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Co-Investigator(Renkei-kenkyūsha) |
Yoneyama Tohru 弘前大学, 医学研究科, 助教 (50587649)
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Project Period (FY) |
2013-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
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Keywords | 神経周囲浸潤 / 前立腺癌 / ファージディスプレイ / 神経周膜細胞 / インテグリンα6 / CXCR4 / ラミニン結合糖鎖 |
Outline of Final Research Achievements |
Perineural invasion (PNI) is important mechanism for extra-capsular extension of prostate cancer (PC). In this study, we identified integrin α6 and laminin binding glycan (LNBG) on α-dystroglycan were important molecules for PNI of PC by using phage display screening and several molecular cell biologic analysis. We found that LNBG expressing PC cells without expression of integrin α6 inhibited perineural invasion capacity, functioning as a tumor suppressor. Both LNBG depletion and up-regulation of integrin α6 of PC cells and activation of SDF-1-CXCR4 signaling requried by enhancement of perineural invasion capacity of PC cells.
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Report
(5 results)
Research Products
(15 results)
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[Presentation] Role of anti-metastatic laminin-binding O-glycan on α-dystroglycan regulated by miR-X in prostate cancer.2016
Author(s)
Tohru Yoneyama, Naomi Fujita, Hiromichi Imamura, Akiko Okamoto, Hayato Yamamoto, Kazuyuki Mori, Shingo Hatakeyama, Yasuhiro Hashimoto, Takuya Koie, Yuki Tobisawa, Minoru Fukuda, Chikara Ohyama
Organizer
European association of Urology annual meeting 2016
Place of Presentation
ミュンヘン、ドイツ
Year and Date
2016-03-11
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