| Project/Area Number |
25861408
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Urology
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| Research Institution | Akita University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 腎移植 / 免疫学的ハイリスク / Rituximab / 二次リンパ組織 / 抗体関連型拒絶反応 / ＢＡＦＦ / Ｂ細胞レパートリー / Bリンパ球 / 形質細胞 / BAFF / リツキシマブ / 2次リンパ節 / 抗CD20抗体 / 脱感作療法 / CD138 |
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| Outline of Final Research Achievements |
<Introduction and Objective> Although CD20+ cells in peripheral blood and spleen are consistently depleted in patients receiving Rituximab (RIT), the clinical effects are heterogeneous, probably related to differences in the depleting effects of lymph node(LN)s. <Methods> 52 patients with immunological high risks received a single dose of RIT at 3 weeks before kidney transplant. Immunohistochemical intensity of B cell subsets (CD20, CD27, CD79a, and CD138) in LN was scored. Serum BAFF levels post-transplant were measured by ELISA. <Results> The intensity score of CD138 in LNs was significantly higher in ABMR patients (p<0.01) than those in non-ABMR. The intensity score of CD138 in LNs, and low serum BAFF level at 7 days before transplant were significantly associated with the occurrence of ABMR. <Conclusion> In immunological high risk kidney transplant recipients receiving RIT before transplant, the plasma cell intensity in LNs and low serum BAFF level were risk factors of ABMR.
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