| Project/Area Number |
25861411
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Urology
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| Research Institution | Gunma University |
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Principal Investigator |
ARAI SEIJI 群馬大学, 医学部附属病院, 助教 (10636210)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 前立腺癌 / CRPC / CTOS法 / スフェロイド / アンドロゲン / 組織内アンドロゲン代謝 / 去勢抵抗性前立腺癌 / 癌細胞初代培養 |
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| Outline of Final Research Achievements |
In this study, I tried to establish cancer tissue-originated spheroid (CTOS) from castration resistant prostate cancer (CRPC) tissues by using CTOS method. Unfortunately, however, it was impossible to make it probably due to the problems of tissue collections and an original feature of prostate cancer cells that is difficulties of establishment of primary culture from prostate cancer patient tissues. In CRPC tissues, DHEA-S was most existing androgens. Moreover, the DHEA-S concentrations in CRPC tissues were highly correlated with the serum DHEA-S concentrations, which suggest that supply of DHEA-S from serum is important for the maintenance of androgens in CRPC tissues.
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