The mechanism of prostate cancer progression via the macrophage infiltration into prostate cancer microenvironment

Research Project

Project/Area Number	25861413
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Urology
Research Institution	Kanazawa University
Principal Investigator	IZUMI Kouji 金沢大学, 医学系, 特任助教 (80646787)
Project Period (FY)	2013-04-01 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000) Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000) Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	前立腺癌 / 転移 / ケモカイン / マクロファージ / 腫瘍随伴性マクロファージ / CCL2 / CCL17 / CCL22
Outline of Final Research Achievements	Human prostate cancer cells with high metastatic ability can secrete more CCL2 than those with low metastatic ability and CCL2 can induce prostate cancer cell migration, regardless of the presence of the suppression of androgen/androgen receptor signal. In addition, CCL2 induce the infiltration of macrophages into prostate cancer tissue, and then chemokines secreted by infiltrated macrophages can induce prostate cancer migration.