| Project/Area Number |
25861425
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Urology
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| Research Institution | Okayama University |
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Principal Investigator |
HUANG PENG 岡山大学, 医歯(薬)学総合研究科, 助教 (00610841)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 遺伝子治療 / 癌ワクチン / 骨髄系免疫抑制細胞 / REIC/Dkk3 / REIC/DKK-3 / MDSC / REIC/Dkk-3 / 樹状細胞 |
|---|
| Outline of Final Research Achievements |
In-situ gene therapy of cancer suppressor gene REIC / Dkk-3 against solid cancer, displayed that the synergistic effects of the "activation of the anti-cancer immunity" and "selective apoptosis of cancer cells", has been demonstrated in several animal models. In this study, REIC / Dkk-3 protein had been elucidated that the suppressive effect on the differentiation of MDSC, furthermore, the mechanism also be verify.
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