Inhibitory effect of oxygen nano-bubble water on urinary stone formation

• Project/Area Number: 25861442
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Urology
• Research Institution: Nagoya City University
• Principal Investigator: Hirose Yasuhiko 名古屋市立大学, 医学(系)研究科(研究院), 研究員 (60381894)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: Kidney stone / Inflammation / Oxygen nano-bubble / Hyperoxaluria / ナノバブル水 / 尿路結石 / 抗炎症作用 / ナノバブル

Outline of Final Research Achievements

Kidney stone resembles arteriosclerosis in the mechanism, calcification composition and epidemiology. Water including oxygen nano-bubbles (nanometer-sized bubbles generated from oxygen microbubbles; ONB water) has anti-inflammatory effects. Based on these anti-inflammatory effects, ONB water has been reported as a useful therapy for atherosclerosis. Therefore, we investigated the inhibitory effects of ONB water on kidney stone formation using a hyperoxaluric rat model. Our results suggest that ONB water reduces crystal retention in hyperoxaluric rats due to decreased renal tubular cell injury and resulting expression of crystal binding molecules (osteopontin: OPN and hyaluronic acid: HA).

Research Products

• [Journal Article] Oxygen nano-bubble water reduces calcium oxalate deposits and tubular cell injury in ethylene glycol-treated rat kidney. (2013)
  • Author(s): Hirose Y, Yasui T, Taguchi K, Fujii Y, Niimi K, Hamamoto S, Okada A, Kubota Y, Kawai N, Itoh Y, Tozawa K, Sasaki S, Kohri K.
  • Journal Title: Urolithiasis. Volume: 41 Issue: 4 Pages: 279-294
  • DOI: 10.1007/s00240-013-0576-5
  • Peer Reviewed
• [Presentation] Inhibitory effect of rooibos tea on urinary stone formation in a rat model (2016)
  • Author(s): Yasuhiko H, Kazumi T, Yasuhiro F, Kazuhiro N, Masayuki U, Takahiro K, Masahito H, Atsushi O, Keiichi T, Kenjiro K, Takahiro Y, Mpho M, Allen R
  • Organizer: 第13回国際尿路結石症学会/日本尿路結石症学会第26回学術集会
  • Place of Presentation: 幕張メッセ 国際会議場（千葉県千葉市）
  • Year and Date: 2016-07-19
  • Int'l Joint Research
• [Presentation] 腎結石モデルラットを用いたルイボス茶の結石抑制作用の検討 (2016)
  • Author(s): 廣瀬 泰彦、海野 怜、伊藤 靖彦、藤井 泰普、田口 和己、宇佐美 雅之、濵本 周造、安藤 亮介、岡田 淳志、戸澤 啓一、郡 健二郎、Allen Rodgers、安井 孝周
  • Organizer: 第104回日本泌尿器科学会総会
  • Place of Presentation: 仙台国際センター、東北大学百周年記念会館（宮城県仙台市）
  • Year and Date: 2016-04-23
• [Presentation] 酸素ナノバブル水による尿路結石形成機序の解明と予防法の開発 (2013)
  • Author(s): 廣瀬 泰彦
  • Organizer: 日本尿路結石症学会第23回学術集会
  • Place of Presentation: 学術総合センター（東京）
• [Presentation] Oxygen nano-bubble water exerts inhibitory effects on kidney stone formation by inhibiting renal tubular cell injury (2013)
  • Author(s): Yasuhiko Hirose
  • Organizer: AUA annual meeting
  • Place of Presentation: San Diego Convention Center( San Diego, USA)