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Photodynamic diagnosis reinforces the prediction for the prognosis of castration resistant prostate cancer

Research Project

Project/Area Number 25861445
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Urology
Research InstitutionNara Medical University

Principal Investigator

ANAI Satoshi  奈良県立医科大学, 医学部, 助教 (70526699)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords去勢抵抗性前立腺癌 / 低侵襲検査 / 蛍光細胞診 / 尿細胞診 / 予後予測 / 治療効果予測 / PTEN
Outline of Final Research Achievements

Castration Resistant Prostate Cancer (CRPC) comprises a large portion of cause of death among prostate cancer patients. In about 30% of CRPC cases, Prostate Specific Antigen (PSA), the most reliable marker for diagnosis and assessment of the therapeutic value, is not associated with the disease progression. As a result, developing a useful treatment in terms of the predictor of therapeutic value and prognosis was a pressing issue for us to be resolved.
We have been developing the photodynamic diagnosis (PDD) using patients’ urine for the detection of prostate cancer. In this study, PDD is applied to the diagnosis for CRPC. Namely, Protoporphyrin IX (PpIX) can be detected in CRPC patients’ urine and the intensity of PpIX can be quantified by the spectrophotometer. Moreover, the deletion of PTEN, which is known as the biomarker for the curative therapy such as radiation and operation, can be detected in CRPC patients’ urine by FISH. About 40 % of CPRC appeared PTEN deletion by FISH.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (4 results)

All 2015 2014 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 3 results) Presentation (1 results)

  • [Journal Article] Protoporphyrin IX induced by 5-aminolevulinic acid in bladder cancer cells in voided urine can be extracorporeally quantified using a spectrophotometer.2015

    • Author(s)
      Nakai Y, Anai S, Onishi S, Masaomi K, Tatsumi Y, Miyake M, Chihara Y, Tanaka N, Hirao Y, Fujimoto K.
    • Journal Title

      Photodiagnosis Photodyn Ther.

      Volume: 13 Issue: 2 Pages: 282-288

    • DOI

      10.1016/j.pdpdt.2014.12.010

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Photodynamic diagnosis of shed prostate cancer cells in voided urine treated with 5-aminolevulinic acid.2014

    • Author(s)
      Nakai Y, Anai S, Kuwada M, Miyake M, Chihara Y, Tanaka N, Hirayama A, Yoshida K, Hirao Y, Fujimoto K.
    • Journal Title

      BMC Urol.

      Volume: 3 Issue: 1

    • DOI

      10.1186/1471-2490-14-59

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Diagnostic approach for cancer cells in urine sediments by 5-aminolevulinic acid-based photodynamic detection in bladder cancer.2014

    • Author(s)
      Miyake M, Nakai Y, Anai S, Tatsumi Y, Kuwada M, Onishi S, Chihara Y, Tanaka N, Hirao Y, Fujimoto K.
    • Journal Title

      Cancer Sci.

      Volume: 105 Issue: 5 Pages: 616-22

    • DOI

      10.1111/cas.12393

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] The sensitivity of the novel fluorescent urine cytology using 5-aminolevulinic acid (5-ALA) is higher than the conventional urine cytology

    • Author(s)
      Satoshi Anai
    • Organizer
      American Urological Association Annual Meeting
    • Place of Presentation
      Orlando, FL, USA
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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