Elucidation of signaling pathwawy targeting to the prolyl isomerase Pin1 in progression of castration resistant prostate cancer
| Project/Area Number |
25861451
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Urology
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| Research Institution | Keio University |
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Principal Investigator |
YASUMIZU Yota 慶應義塾大学, 医学部, 共同研究員 (40464854)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 去勢抵抗性前立腺癌 / プロリン異性化酵素 / リン酸化 / 転写後翻訳 / Pin1 |
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| Outline of Final Research Achievements |
The prolyl isomerase Pin1 regulates phosphorylated status of proteins by catalyzing the cis-trans isomerization of phosphorylated Ser/Thr and Pro motifs, and plays an important role in cancer progression. Strong expression of Pin1 in prostate cancer samples taken from prostatectomy was a potent predictive factor for prognosis. In vitro, inhibition of Pin1 showed significant anti-tumor efficacy for castration resistant prostate cancer cells. These results suggested Pin1may serve as a promising therapeutic target for castration resistant prostate cancer.
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Report
(3 results)
Research Products
(3 results)
