Elucidation of signaling pathwawy targeting to the prolyl isomerase Pin1 in progression of castration resistant prostate cancer

Research Project

Project/Area Number	25861451
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Urology
Research Institution	Keio University
Principal Investigator	YASUMIZU Yota 慶應義塾大学, 医学部, 共同研究員 (40464854)
Project Period (FY)	2013-04-01 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000) Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000) Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords	去勢抵抗性前立腺癌 / プロリン異性化酵素 / リン酸化 / 転写後翻訳 / Pin1
Outline of Final Research Achievements	The prolyl isomerase Pin1 regulates phosphorylated status of proteins by catalyzing the cis-trans isomerization of phosphorylated Ser/Thr and Pro motifs, and plays an important role in cancer progression. Strong expression of Pin1 in prostate cancer samples taken from prostatectomy was a potent predictive factor for prognosis. In vitro, inhibition of Pin1 showed significant anti-tumor efficacy for castration resistant prostate cancer cells. These results suggested Pin1may serve as a promising therapeutic target for castration resistant prostate cancer.

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(3 results)