The regulation of prostate cancer invasion by GEP100-Arf6-AMAP1 pathway

• Project/Area Number: 25861452
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Urology
• Research Institution: Keio University
• Principal Investigator: KANEKO gou 慶應義塾大学, 医学部, 共同研究員 (20445266)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 前立腺癌 / 再発因子 / 浸潤

Outline of Final Research Achievements

The morbidity of prostate cancer has been rapidly increasing, therefore, it is expected that radical prostatectomy for localized prostate cancer will increase in the future. Thus, the elucidation of the novel and strong predictor for recurrence after surgery is essential from the viewpoint of medical economy. It is suggested that the strong expression of signal of GEP100-Arf6-AMAP1 pathway is a useful predictor for PSA recurrence after radical prostatectomy from the present study.