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Functional analysis of TAp63alpha-Bnc1 signal in oocyte

Research Project

Project/Area Number 25861462
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Obstetrics and gynecology
Research InstitutionTohoku University

Principal Investigator

SAKAMOTO Masahiro  東北大学, 大学病院, 技能補佐員 (50645299)

Research Collaborator IHARA Motomasa  
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords生殖 / 卵成熟 / TAp63α / 卵母細胞 / 不妊 / アポトーシス
Outline of Final Research Achievements

Basonuclin1 (Bnc1) gene is specifically expressed in germ cells and keratinocyte. We have focused on the mechanism to regulate Bnc1 expression level in mouse GV stage oocyte. Microinjection of TAp63 alpha mRNA into mature GV stage oocytes did not increase the Bnc1 gene expression. Using Mass Spectrography, We have identified the novel Bnc1-binding proteins and possibility that TAp63 alpha gene expression is regulated by Bnc1 and a novel Bnc1-binding protein“X”.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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