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Establishment of novel immunotherapy against gynecologic cancer based on the mechanism of maternal-fetal immune tolerance.

Research Project

Project/Area Number 25861467
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Obstetrics and gynecology
Research InstitutionAkita University

Principal Investigator

Shimizu Dai  秋田大学, 医学部, 講師 (60400503)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords母児免疫寛容 / 癌免疫療法
Outline of Final Research Achievements

We investigated the expression of HLA-G in human gynecologic cancer cell-lines and identified its expression in cervical cancer cell-line, Hela and ovarian cancer cell-line, SK-OV-3 by RT-PCR. We also established their stable transfectants that integrated luciferase reporter gene. We examined cytotoxic assay of NK cell (NK-92: human NK cell-line derived from non-hodgkin’s lymphoma) by co-culture with human gynecologic cancer cells with or without anti-HLA-G neutralization antibody. We continue the examination aim at the clinical application of our strategy against cancer.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (6 results)

All 2015 2014

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (4 results)

  • [Journal Article] Impact of adjuvant chemotherapy for stage I ovarian carcinoma with intraoperative tumor capsule rupture.2015

    • Author(s)
      Shimizu D, Sato N, Sato T, Makino K, Kito M, Shirasawa H, Kumagai J, Terada Y.
    • Journal Title

      J Obstet Gynaecol Res

      Volume: 41 Issue: 3 Pages: 432-439

    • DOI

      10.1111/jog.12551

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Efficient Screening Strategy for Lynch Syndrome in Japanese Endometrial Cancer2015

    • Author(s)
      Sugawara T, Sato N, Shimizu D, Sato T, Makino K, Kito M, Tamura D, Kato A, Terada Y
    • Journal Title

      The Tohoku Journal of Experimental Medicine

      Volume: 235 Issue: 2 Pages: 117-125

    • DOI

      10.1620/tjem.235.117

    • NAID

      130004822436

    • ISSN
      0040-8727, 1349-3329
    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] 会陰部に発育した消化管間質腫瘍(GIST)の1例2014

    • Author(s)
      木藤正彦,牧野健一,上野真侑,菅原多恵,佐藤敏治,清水大,佐藤直樹,寺田幸弘
    • Organizer
      第62回北日本産科婦人科学会
    • Place of Presentation
      ホテル金沢
    • Year and Date
      2014-09-27 – 2014-09-28
    • Related Report
      2014 Research-status Report
  • [Presentation] 子宮魚2014

    • Author(s)
      木藤正彦,佐藤直樹,清水大,佐藤敏治,牧野健一,菅原多恵,寺田幸弘
    • Organizer
      第66回日本産科婦人科学会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2014-04-18 – 2014-04-20
    • Related Report
      2014 Research-status Report
  • [Presentation] 外陰部リンパ管拡張症に合併した血管線維腫の1 例2014

    • Author(s)
      牧野健一,清水大,木藤正彦,菅原多恵,佐藤敏治,佐藤直樹,寺田幸弘
    • Organizer
      第66回日本産科婦人科学会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2014-04-18 – 2014-04-20
    • Related Report
      2014 Research-status Report
  • [Presentation] 若年で発症し,卵巣腫瘍との鑑別が困難であった結腸間膜原発血管周皮腫(hemangiopericytoma)の1 症例2014

    • Author(s)
      菅原多恵,木藤正彦,牧野健一,佐藤敏治,清水大,佐藤直樹,寺田幸弘
    • Organizer
      第66回日本産科婦人科学会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2014-04-18 – 2014-04-20
    • Related Report
      2014 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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