| Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
We investigated the expression of HLA-G in human gynecologic cancer cell-lines and identified its expression in cervical cancer cell-line, Hela and ovarian cancer cell-line, SK-OV-3 by RT-PCR. We also established their stable transfectants that integrated luciferase reporter gene. We examined cytotoxic assay of NK cell (NK-92: human NK cell-line derived from non-hodgkin’s lymphoma) by co-culture with human gynecologic cancer cells with or without anti-HLA-G neutralization antibody. We continue the examination aim at the clinical application of our strategy against cancer.
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