| Project/Area Number |
25861468
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Gunma University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | LHR / rat-ovary / IL-6 / TNF-α / LH受容体 / TNFα / 卵巣顆粒膜細胞 / 子宮内膜症 |
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| Outline of Final Research Achievements |
We examined the mechanism of regulation of LH-receptor expression in granulosa cell of rat ovary. Under normal physiological conditions, IL-6 is produced in granulosa cells, but some studies have suggested that IL-6 negatively affects reproductive functions in the ovary. Our previous study showed that FSH upregulates LH-receptor expression. We examined the effect of IL-6 on FSH-induced LHR mRNA and protein expression levels and mechanisms of regulation in rat primary granulosa cells. Our results indicated that IL-6 increased FSH-induced expression of LHR. We also studied the effect of TNFα, and our results indicated TNFα decreased FSH-induced expression of LHR.
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