• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

the mechanism of regulation of LH-receptor expression in granulosa cell of rat ovary.

Research Project

Project/Area Number 25861468
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Obstetrics and gynecology
Research InstitutionGunma University

Principal Investigator

YAMASHITA SOICHI  群馬大学, 医学部附属病院, 講師 (10516412)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
KeywordsLHR / rat-ovary / IL-6 / TNF-α / LH受容体 / TNFα / 卵巣顆粒膜細胞 / 子宮内膜症
Outline of Final Research Achievements

We examined the mechanism of regulation of LH-receptor expression in granulosa cell of rat ovary. Under normal physiological conditions, IL-6 is produced in granulosa cells, but some studies have suggested that IL-6 negatively affects reproductive functions in the ovary. Our previous study showed that FSH upregulates LH-receptor expression. We examined the effect of IL-6 on FSH-induced LHR mRNA and protein expression levels and mechanisms of regulation in rat primary granulosa cells. Our results indicated that IL-6 increased FSH-induced expression of LHR. We also studied the effect of TNFα, and our results indicated TNFα decreased FSH-induced expression of LHR.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (8 results)

All 2015 2014 2013 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (6 results)

  • [Journal Article] IL-6 up-regulates the expression of rat LH receptors during granulosa cell differentiation.2014

    • Author(s)
      Imai F, Kishi H, Nakao K, Nishimura T, Minegishi T.
    • Journal Title

      Endocrinology

      Volume: 155(4) Issue: 4 Pages: 1436-1444

    • DOI

      10.1210/en.2013-1821

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The ERK1/2 pathway regulates testosterone synthesis by coordinately regulating the expression of steroidogenic genes in Leydig cells.2013

    • Author(s)
      Matzkin ME, Yamashita S, Ascoli M
    • Journal Title

      Molecular and Cellular Endocrinology

      Volume: 370 Issue: 1-2 Pages: 130-137

    • DOI

      10.1016/j.mce.2013.02.017

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 顆粒膜細胞におけるLH受容体発現に対するTNF-αによる作用機序の解明2015

    • Author(s)
      中尾光資郎
    • Organizer
      第67回 日本産婦人科学会
    • Place of Presentation
      横浜
    • Year and Date
      2015-04-09 – 2015-04-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] ゴナドトロピン受容体の機能にその構造および生理活性物質が及ぼす影響2015

    • Author(s)
      岸裕司
    • Organizer
      第67回 日本産婦人科学会
    • Place of Presentation
      横浜
    • Year and Date
      2015-04-09 – 2015-04-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] curreny status and problems regarding ART in Japan2015

    • Author(s)
      今井文晴
    • Organizer
      第67回 日本産婦人科学会
    • Place of Presentation
      横浜
    • Year and Date
      2015-04-09 – 2015-04-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] 婦人科悪性腫瘍手術において、リンパ節郭清術施行時の後腹膜縫合の有無に関わる有害事象についての当科における研究

    • Author(s)
      木暮圭子
    • Organizer
      第65回日本産婦人科学会学術講演会
    • Place of Presentation
      札幌市
    • Related Report
      2013 Research-status Report
  • [Presentation] 広汎な深部静脈血栓症に対し外科的血栓除去を施行した卵巣がんの一例

    • Author(s)
      尾池妙
    • Organizer
      第126回関東連合産科婦人科学会学術集会
    • Place of Presentation
      浜松市
    • Related Report
      2013 Research-status Report
  • [Presentation] 莢膜細胞腫によるtrue Meigs症候群の一例

    • Author(s)
      阿部由佳
    • Organizer
      第126回関東連合産科婦人科学会学術集会
    • Place of Presentation
      浜松市
    • Related Report
      2013 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi