| Project/Area Number |
25861475
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Research Institute, International Medical Center of Japan |
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Principal Investigator |
HAJIME Oishi 独立行政法人国立国際医療研究センター, その他部局等, その他 (40401088)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | AMPK / SIRT3 / 卵巣 / 顆粒膜細胞 / ステロイド合成 / LKB1 |
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| Outline of Final Research Achievements |
The aim of the study is to clarify the involvement of the LKB1-AMPK system in the estrogen responsive organs such as ovary, uterus, and mammary gland. The LKB1 phosphorylates AMPK1, which controls and senses energy balance in the cell. The regulation of both steroidogenesis and cell proliferation by energy sensing system were examined in these organs. We also investigated the function of SIRT3, one of the interacting factor of AMPK, in the ovary. The biosynthesis of progesterone is found to be regulated by SIRT3.
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