histological diagnosis of amniotic fluid embolism using immunostaining of zinc coproporphyrin1
Project/Area Number |
25861485
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Obstetrics and gynecology
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Research Institution | Hamamatsu University School of Medicine |
Principal Investigator |
Furuta Naomi 浜松医科大学, 医学部附属病院, 助教 (80647595)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | 胎便 / 胎盤 / 抗亜鉛コプロポルフィリン抗体 / 卵膜 / 亜鉛コプロポルフィリン |
Outline of Final Research Achievements |
Immunoreactivity of ZnCP-Ⅰ clearly and specifically identified meconium in the placenta,fetal membrane,and umbilical cord.Meconium was detected in clear amniotic fluid at delivery, especially in cases of premature rupture of membrane,suggesting previous exposure.We suggested that the meconium effect at onset of labor as a signal of the fetal maturation.Immunohistochemical detection of ZnCP-I is a highly sensitive histological diagnosis .Clear immunostaining of ZnCP-Ⅰwas detected in the lung tissues. In cases of acute or subacute exposure to meconium, ZnCP-I immunostainning was obsterved in dependent of macrophage-specific CD68. By contrast, ZnCP-I and CD68 was obserbed in the identical cells at the case of chronic exposure to meconium. Monoclonal antibody for ZnCP-Ⅰ would be useful to establish the histological diagnostic criteria for the lung of meconium aspiration syndrome.
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Report
(4 results)
Research Products
(10 results)
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[Journal Article] Morphological characteristics of the placental basal plate in IVF pregnancies: a possible association with the amount of bleeding in delivery.2015
Author(s)
Nakamura Y, Yaguchi C, Itoh H, Sakamoto R, Kimura T, Furuta N, Uchida T, Tamura N, Suzuki K, Sumimoto K, Matsuda Y, Matsuura T, Nishimura M, Kanayama N.
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Journal Title
Human Pathology
Volume: 46
Pages: 1171-1179
Related Report
Peer Reviewed
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[Journal Article] Histological characteristics of the myometrium in the postpartum hemorrhage of unknown etiology: a possible involvement of local immune reactions.2015
Author(s)
Farhana M, Tamura N, Mukai M, Ikuma K, Koumura Y, Furuta N, Yaguchi C, Uchida T, Suzuki K, Sugihara K, Itoh H, Kanayama N.
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Journal Title
Journal of Reproductive Immunology
Volume: 110
Pages: 74-80
Related Report
Peer Reviewed
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[Journal Article] Morphological characteristics of the placental basal plate in IVF pregnancies: a possible association with the amount of bleeding in delivery2015
Author(s)
Yuki Nakamura,Chizuko yaguchi,Hiroaki Itoh Ryoko Sakamoto,Takako Kimura,Naomi Furuta,Toshiyuki Uchida,Naoaki Tamura,Kazunao Suzuki,Kazuhiro Sumimoto,Yumiko Matsuda,Toshiki Matsura,Mitsura Nishimura,Naohiro Kanayama
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Journal Title
Human Pathology
Volume: inprint
Issue: 8
Pages: 1171-1179
DOI
Related Report
Peer Reviewed / Open Access
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