| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
Immunoreactivity of ZnCP-Ⅰ clearly and specifically identified meconium in the placenta,fetal membrane,and umbilical cord.Meconium was detected in clear amniotic fluid at delivery, especially in cases of premature rupture of membrane,suggesting previous exposure.We suggested that the meconium effect at onset of labor as a signal of the fetal maturation.Immunohistochemical detection of ZnCP-I is a highly sensitive histological diagnosis .Clear immunostaining of ZnCP-Ⅰwas detected in the lung tissues. In cases of acute or subacute exposure to meconium, ZnCP-I immunostainning was obsterved in dependent of macrophage-specific CD68. By contrast, ZnCP-I and CD68 was obserbed in the identical cells at the case of chronic exposure to meconium. Monoclonal antibody for ZnCP-Ⅰ would be useful to establish the histological diagnostic criteria for the lung of meconium aspiration syndrome.
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