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Evaluation of a novel amino peptidase Laeverin especially expressed on human extravillous trophoblast.

Research Project

Project/Area Number 25861490
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Obstetrics and gynecology
Research InstitutionKyoto University

Principal Investigator

HORIE AKIHITO  京都大学, 医学(系)研究科(研究院), 助教 (30535836)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
KeywordsEVT / 免疫回避 / 血清マーカー / laeverin
Outline of Final Research Achievements

We made the study of laeverin which was released from EVT and combined with immune cells. As recombinant laeverin altered the morphology of villous cells, we suspected laeverin was associated with the immunological escape mechanism.
And we also evaluated the possibility of laeverin could be a prospective marker for the PIH. As we detected the declining trend for the laeverin serum level of PIH patients, we suspected laeverin would be the predictive marker.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (10 results)

All 2015 2014 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (6 results) (of which Invited: 1 results) Book (3 results)

  • [Journal Article] Prediction of possibility of non-IVF pregnancy after laparoscopic surgery in infertile women with endometriosis using Endometriosis Fertility Index2015

    • Author(s)
      Akihito HORIE, Asuka OKUNOMIYA, Tsukasa BABA, Kaoru ABIKO, Ken YAMAGUCHI, Noriomi MATSUMURA, Yukiyasu SATO, Ikuo KONISHI
    • Journal Title

      ADVANCES IN OBSTETRICS AND GYNECOLOGY

      Volume: 67

    • NAID

      130005101920

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 子宮内膜症の腹膜病変の形成におけるversicanの役割とその制御因子の検討2015

    • Author(s)
      谷 洋彦、堀江昭史、杉並 興、宮﨑有美子、上田 匡、佐藤幸保、小西郁生
    • Organizer
      第36回日本エンドメトリオーシス学会学術講演会
    • Place of Presentation
      東京
    • Year and Date
      2015-01-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] 着床期子宮内膜におけるversicanの発現とその機能に関する検討2014

    • Author(s)
      宮﨑有美子、堀江昭史、佐藤幸保、杉並 興、谷 洋彦、上田 匡、小西郁生
    • Organizer
      第59回日本生殖医学会学術講演会
    • Place of Presentation
      東京
    • Year and Date
      2014-12-04 – 2014-12-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] 子宮内膜症女性の正常腹膜ではextracellular matrixの構成成分であるversicanの発現が増強している2014

    • Author(s)
      谷 洋彦、堀江昭史、佐藤幸保、杉並 興、宮﨑有美子、上田 匡、小西郁生
    • Organizer
      第59回日本生殖医学会学術講演会
    • Place of Presentation
      東京
    • Year and Date
      2014-12-04 – 2014-12-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] Fertility-recovering surgery for endometriosis, adenomyosis, and diffuse leiomyomatosis2014

    • Author(s)
      Akihito Horie
    • Organizer
      Japan-Philippines Conference for Advancement of Clinical Practice
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2014-06-26 – 2014-06-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 乳癌患者の卵巣機能の評価と管理について2014

    • Author(s)
      堀江 昭史
    • Organizer
      KYOTO Breast Cancer Summit
    • Place of Presentation
      京都
    • Year and Date
      2014-06-14
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Laeverin, a human extravillous trophoblast-specific peptidase, regulates trophoblast migration

    • Author(s)
      Hirohiko Tani
    • Organizer
      The American College of Obstetricians and Gynecologists( ACOG) 61st Annual Clinical Meeting
    • Place of Presentation
      New Orleans (USA)
    • Related Report
      2013 Research-status Report
  • [Book] 卵巣がんリスク低減手術 (Risk Reducing Salpingo-Oopholectomy; RRSO)2015

    • Author(s)
      堀江 昭史、馬場 長、小西 郁生
    • Publisher
      MEDICAL VIEW
    • Related Report
      2014 Annual Research Report
  • [Book] よりよい婦人科手術のための器具の使い方~バイポーラ電気メスの使い方2014

    • Author(s)
      馬場 長、堀江 昭史、小西 郁生
    • Publisher
      MEDICAL VIEW
    • Related Report
      2014 Annual Research Report
  • [Book] 産婦人科―無排卵2014

    • Author(s)
      堀江 昭史
    • Publisher
      今日の臨床サポート
    • Related Report
      2014 Annual Research Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

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