Genomic factor associated with HPV persistent infection
Project/Area Number |
25861498
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Obstetrics and gynecology
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Research Institution | Nagasaki University |
Principal Investigator |
ABE Syuhei 長崎大学, 医歯薬学総合研究科(医学系), 助教 (50549590)
|
Project Period (FY) |
2013-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 子宮頸癌 / コピー数多型 / DEFB4 / HPV |
Outline of Final Research Achievements |
We obtained three heads of results in this study. (1) When considering the cervical cancer prevention and health check system in Japan, to clarify the HPV genotyping of the HPV16 and HPV52 is important. (2) HPV16 and/or 52 genotyping and viral load of cervical scraping cells are useful as a molecular marker to estimate the changes in the cervical cytology. (3) Latest knowledge of an association between cervical cancer and DEFB4 copy-number variation, it was considered useful for the diagnosis and prevention of the onset of cervical cancer.
This study now performs exsome analysis and methylation array analysis using the next-generation sequencing method is expected to be connected to the identification of more host side factors.
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Report
(3 results)
Research Products
(13 results)
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[Journal Article] Single human papillomavirus 16 or 52 infection and later cytological findings in Japanese women with NILM or ASC-US.2014
Author(s)
Abe S, Miura K, Kinoshita A, Mishima H, Miura S, Yamasaki K, Hasegawa Y, Higashijima A, Jo O, Yoshida A, Kaneuchi M, Yoshiura K, Masuzaki H.
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Journal Title
Journal of Human Genetics
Volume: 59 (5)
Issue: 5
Pages: 251-255
DOI
Related Report
Peer Reviewed
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[Journal Article] Single human papillomavirus 16 or 52 infection and later cytological findings in Japanese women with NILM or ASC-US.2014
Author(s)
Abe S, Miura K, Kinoshita A, Mishima H, Miura S, Yamasaki K, Hasegawa Y, Higashijima A, Jo O, Yoshida A, Kaneuchi M, Yoshiura KI, Masuzaki H.
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Journal Title
Journal of Human Genetics
Volume: -
Related Report
Peer Reviewed
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[Journal Article] Predominantly placenta-expressed mRNAs in maternal plasma as predictive markers for twin-twin transfusion syndrome.2014
Author(s)
Miura K, Higashijima A, Miura S, Mishima H, Yamasaki K, Abe S, Hasegawa Y, Kaneuchi M, Yoshida A, Kinoshita A, Yoshiura K, Masuzaki H.
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Journal Title
Prenatal Diagnosis
Volume: 34
Pages: 345-349
Related Report
Peer Reviewed
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[Journal Article] Copy number variation of the antimicrobial-gene, defensin beta 4, is associated with susceptibility to cervical cancer.2013
Author(s)
Abe S, Miura K, Kinoshita A, Mishima H, Miura S, Yamasaki K, Hasegawa Y, Higashijima A, Jo O, Sasaki K, Yoshida A, Yoshiura K, Masuzaki H.
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Journal Title
Journal of Human Genetics
Volume: 58
Pages: 250-253
Related Report
Peer Reviewed
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[Journal Article] Characterization of placenta-specific microRNAs in fetal growth restriction pregnancy.2013
Author(s)
Higashijima A, Miura K, Mishima H, Kinoshita A, Jo O, Abe S, Hasegawa Y, Miura S, Yamasaki K, Yoshida A, Yoshiura K, Masuzaki H.
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Journal Title
Prenatal Diagnosis
Volume: 33
Pages: 214-222
Related Report
Peer Reviewed
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