| Project/Area Number |
25861503
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
MORI Taisuke 京都府立医科大学, 医学(系)研究科(研究院), 助教 (00569824)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | ホルモン依存性腫瘍 / 子宮体癌 / エストロゲン依存性疾患 / エストロゲン関連受容体 |
|---|
| Outline of Final Research Achievements |
We investigated whether estrogen-related receptor (ERR) alpha influences epithelial-mesenchymal transition in uterine endometrial cancer. ERR alpha inactivated E-cadherin expression in one of endometrial cancer cell lines, however, it did not change the expression other mesenchymal markers, such as, N-cadherin and vimentin. Instead, ERR alpha stimulate VEGF expression and tranｓcriptional activity leading to induce angiogenesis in endometrial cancer. These data suggest ERR alpha could be a novel target for the endometrial cancer.
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