The roles and clinical significance of microRNAs in cervical cancer.

• Project/Area Number: 25861506
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Obstetrics and gynecology
• Research Institution: Keio University
• Principal Investigator: Nobumaru Hirao 慶應義塾大学, 医学部, 講師 (80327593)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 子宮頸癌 / micro RNA / 細胞増殖 / microRNA / マイクロRNA / miRNA

Outline of Final Research Achievements

Using the same cervical cancer patient's serum obtained at 2 points – before treatment and after treatment, we identified microRNAs to be highly expressed in cervical cancer. Micro RNAs that were equal to or greater than 4 times before treatment was 12. Out of these 12 micro RNAs, miR-1246, miR-4306 and miR-1290 were identified. These three micro RNA was novel micro RNAs, these has not been reported in cervical cancer. Proliferating assay revealed that miR-1290 was involved in cell proliferation. miR-1290 there is likely to be involved in the malignant transformation of cervical cancer.