| Project/Area Number |
25861509
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Showa University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 胎児発育 / 妊娠初期 / 流産 / 染色体異常 / 胎児発育不全 / 胎児頭殿長 / 常位胎盤早期剥離 / 妊娠高血圧症候群 / DIC / 超音波検査 / 胎盤機能 / 胎児循環不全 / 臍帯静脈血 / 予後予測 / 妊娠初期の超音波計測 / 播種性血管内凝固 |
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| Outline of Final Research Achievements |
We demonstrated that not only spontaneous abortion and chromosomal abnormalities, as well as small-for-gestational age (SGA) with or without chromosomal abnormalities, are frequently observed in cases involving a short CRL 11-13 weeks’ gestation based on the expected date of confinement (EDC) determined at 9 weeks’ gestation. The frequency of abortion was 7.1% among cases of a short crown-rump length (CRL) at 11-13 weeks’ gestation, compared to only 0.9% of fetuses with a normal CRL. The precise gestational age might not be evaluated for the women with irregular menstrual cycle or missing ovulation day. Our methods evaluating fetal growth in first trimester might be thought to fit for those women.
Determining the gestational age according to CRL obtained at 9 weeks’ gestation prior to evaluating fetal morphology assessments of the CRL at 11-13 weeks’ gestation is useful for predicting the incidence of abortion and trisomy 18, as well as fetal growth restriction later in pregnancy.
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